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Type: Artigo
Title: Diagnosis And Treatment Of Chronic Lymphocytic Leukemia: Recommendations From The Brazilian Group Of Chronic Lymphocytic Leukemia
Author: Rodrigues
Celso Arrais; Gonçalves
Matheus Vescovi; Ikoma
Maura Rosane Valério; Lorand-Metze
Irene; Pereira
André Domingues; Farias
Danielle Leão Cordeiro de; Chauffaille
Maria de Lourdes Lopes Ferrari; Schaffel
Rony; Ribeiro
Eduardo Flávio Oliveira; Rocha
Talita Silveira da; Buccheri
Valeria; Vasconcelos
Yuri; Figueiredo
Vera Lúcia de Piratininga; Chiattone
Carlos Sérgio; Yamamoto
Abstract: Chronic lymphocytic leukemia is characterized by clonal proliferation and progressive accumulation of B-cell lymphocytes that typically express CD19+, CD5+ and CD23+. The lymphocytes usually infiltrate the bone marrow, peripheral blood, lymph nodes, and spleen. The diagnosis is established by immunophenotyping circulating B-lymphocytes, and prognosis is defined by two staging systems (Rai and Binet) established by physical examination and blood counts, as well as by several biological and genetic markers. In this update, we present the recommendations from the Brazilian Group of Chronic Lymphocytic Leukemia for the diagnosis and treatment of chronic lymphocytic leukemia. The following recommendations are based on an extensive literature review with the aim of contributing to more uniform patient care in Brazil and possibly in other countries with a similar social-economic profile.
Subject: Chronic Lymphocytic Leukemia
Editor: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Citation: Revista Brasileira De Hematologia E Hemoterapia . Associação Brasileira De Hematologia E Hemoterapia E Terapia Celular, v. 38, n. 4, p. 346 - 357
Rights: aberto
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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