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Type: Artigo
Title: Mcp-1 Levels Are Associated With Cardiac Remodeling But Not With Resistant Hypertension
Title Alternative: Níveis De Mcp-1 Estão Associados Com Remodelamento Cardíaco Mas Não Com Hipertensão Resistente
Author: Ritter
Alessandra Mileni Versuti; Faria
Ana Paula Cabral de; Sabbatini
Andrea; Corrêa
Nathalia Batista; Brunelli
Veridiana; Modolo
Rodrigo; Moreno
Abstract: Hypertension is a chronic, low-grade inflammation process associated with the release of cytokines and development of target organ damage. Deregulated monocyte chemoattractant protein-1 (MCP-1) levels have been associated with high blood pressure and cardiovascular complications; however, the mechanisms involved are complex and not fully understood. Objective: This study aimed to compare the levels of MCP-1 in patients with resistant (RH) versus mild-to-moderate (HTN) hypertension and their association with the presence or absence of left ventricular hypertrophy (LVH) in all hypertensive subjects. Methods: We enrolled 256 hypertensive subjects: 120 RH and 136 HTN, investigating the relationship between circulating MCP-1 levels and blood pressure, biochemical data, hematologic profile, and cardiac damage within the RH and HTN groups. Plasma MCP-1 levels were measured by ELISA and LVH was assessed by echocardiography. Results: We found no difference in MCP-1 levels between RH and HTN subjects. On the other hand, we encountered lower MCP-1 levels in patients with LVH (105 pg/mL [100 - 260 pg/mL] versus 136 pg/mL (100 - 200 pg/mL), p = 0.005, respectively] compared with those without LVH. A logistic regression model adjusted for body mass index (BMI), age, race, aldosterone levels, and presence of diabetes and RH demonstrated that median levels of MCP-1 (2.55 pg/mL [1.22 - 5.2 pg/mL], p = 0.01) were independently associated with LVH in the entire hypertensive population. Conclusion: Since MCP-1 levels were similar in both RH and HTN subjects and decreased in hypertensive patients with existing LVH, our study suggests a possible downregulation in MCP-1 levels in hypertensive individuals with LVH, regardless of hypertension strata.
Subject: Refractory Hypertension
Monocyte Chemoattractant Proteins
Left Ventricular Hypertrophy
Proteínas Quimioatraentes De Monócitos
Hipertrofia Ventricular Esquerda
Remodelamento Cardíaco
Editor: Sociedade Brasileira de Cardiologia - SBC
Citation: Arquivos Brasileiros De Cardiologia. Sociedade Brasileira De Cardiologia - Sbc, v. 108, n. 4, p. 331 - 338
Rights: aberto
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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