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Type: Artigo
Title: Selective Cox-2 Inhibitor (meloxicam) And Tooth-supporting Bone Quality. A Histomorphometric Study In Rats
Author: Gurgel
Bruno César de Vasconcelos; Almeida
Krysna Torres de; Peixoto
Raniel Fernandes; Lima
Kenio Costa; Kantovitz
Kamila Rosamilia; Humberto Nociti-Junior
Francisco; Toledo
Sergio de
Abstract: The effects of the non-steroidal anti-inflammatory drugs (NSAIDs) on bone quantity and quality were investigated for years. However, there is lack of information on the impact of NSAIDs on the quality of tooth-supporting alveolar bone in absence of periodontal inflammation. Thus, the aim of this study was to evaluate histometrically the influence of a selective COX-2 NSAID (Meloxicam) on the inter-radicular bone mineral density in rats. Forty-nine adult male Wistar rats were randomly divided into four experimental groups: Subcutaneous injection of 0.9% sterile saline for 15 days (G1; n=12) and 45 days (G2; n=11); and subcutaneous injection of Meloxicam for 15 days (G3; n=13) and 45 days (G4; n=13). Mineral density was histometrically determined in the inter-radicular area of the 1st mandibular molars and data analysis performed by two-way ANOVA (a=5%). Results showed no interaction between time and treatment (p>0.05) and that meloxicam did not affect the alveolar bone density. In contrast, it was found that inter-radicular alveolar bone density increased with time (91.88±3.08% and 92.86±2.38% for groups 15 and 45 days, respectively) (p<0.05). Within the limits of this study, daily administration of a selective COX-2 inhibitor (Meloxicam) did not affect the quality of the inter-radicular alveolar bone in absence of periodontal infection.
Subject: Cyclooxygenase-2 Inhibitor
Alveolar Bone Density
Editor: Fundação Odontológica de Ribeirão Preto
Citation: Brazilian Dental Journal. Fundação Odontológica De Ribeirão Preto, v. 28, n. 2, p. 135 - 139
Rights: aberto
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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