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Type: Artigo
Title: Ultrasound-promoted Synthesis Of 3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1-carboximidamides And Anticancer Activity Evaluation In Leukemia Cell Lines
Author: Santos
Eric F. S. dos; Cury
Nathália M.; Nascimento
Tainara A. do; Raminelli
Cristiano; Casagrande
Gleison A.; Pereira
Claudio M. P.; Simionatto
Euclésio; Yunes
José A.; Pizzuti
Abstract: 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4;11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 µmol L-1 and five compounds presented IC50 values around 40 µmol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 µmol L-1.
Subject: Amidinopyrazole
Cytotoxic Activity
Ultrasonic Irradiation
Editor: Sociedade Brasileira de Química
Rights: aberto
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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