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Type: Artigo
Title: Link Between Immunoexpression Of Hmlh1 And Hmsh2 Proteins And Clinical-epidemiological Aspects Of Actinic Cheilitis
Author: Sarmento D.J.S.
Godoy G.P.
Miguel M.C.C.
da Silveira É.J.D.
Abstract: The studies found in the literature associate the immunoexpression of hMLH1 and hMSH2 proteins with histologic aspects, but do not correlate it with clinical and epidemiological data. Objective: To evaluate the immunoexpression of hMLH1 and hMSH2 in actinic cheilitis, correlating it with clinical characteristics. Methods: We analyzed 40 cases. Histological and immunohistochemical analyses were performed. The following clinical variables were evaluated: gender, age range, ethnicity, clinical aspect and occupational sunlight exposure. Statistical evaluation included the Student t-test, while the significance level was set at 5%. Results: Greater immunoexpression of hMLH1 and hMSH2 was observed in females, individuals aged over 40, and mixedrace/ black patients. Furthermore, the immunoexpression of these proteins was greater in actinic cheilitis with a white-colored appearance and in patients without occupational sunlight exposure. No statistical differences were observed for the variables studied. Conclusion: This study uncovered variations of hMLH1 and hMSH2 protein expression upon evaluation of clinical aspects in actinic cheilitis. © 2016 by Anais Brasileiros de Dermatologia.
Subject: Cheilitis
Clinical Diagnosis
Editor: Sociedade Brasileira de Dermatologia
Rights: aberto
Identifier DOI: 10.1590/abd1806-4841.20164800
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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