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|Title:||Use Of Protocol And Evaluation Of Postoperative Residual Curarization Incidence In The Absence Of Intraoperative Acceleromyography - Randomized Clinical Trial|
|Abstract:||Objective: Evaluate the incidence of PORC in the post-anesthesia care unit (PACU) after the use of protocol and absence of intraoperative acceleromyography (AMG). Methods: Randomized clinical trial with 122 patients divided into two groups (protocol and control). Protocol group received initial and additional doses of rocuronium (0.6. mg/kg and 10. mg, respectively); the use of rocuronium was avoided in the final 45. minutes; blockade reversal with neostigmine (50. μg/kg); time ≥ 15. minutes between reversion and extubation. Control: initial and additional doses of rocuronium, blockade reversal, neostigmine dose, and extubation time, all at the discretion of the anesthetist. AMG was used in the PACU and PORC considered at T4/T1 ratio. <. 1.0. Results: The incidence of PORC was lower in protocol group than in control group (25% vs. 45.2%, p = 0.02). In control group, total dose of rocuronium was higher in patients with PORC than without PORC (0.43 vs. 0.35. mg/kg/h, p = 0.03) and the time interval between the last administration of rocuronium and neostigmine was lower (75.0 vs. 101.0. min, p <. 0.01). In protocol group, there was no difference regarding the analyzed parameters (with PORC vs. without PORC). Considering the entire study population and the presence or absence of PORC, total dose of rocuronium was higher in patients with PORC (0.42 vs. 0.31. mg/kg/h, p = 0.01), while the time interval between the last administration of rocuronium and neostigmine was lower (72.5 vs. 99.0. min, p ≤ 0.01). Conclusion: The proposed systematization reduced PORC incidence in PACU in the absence of intraoperative AMG. © 2017.|
Postoperative Residual Curarization
Quantitative Neuromuscular Monitoring
|Editor:||Elsevier Editora Ltda|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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