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Type: Artigo de Periódico
Title: Doxorubicin-functionalized Silica Nanoparticles Incorporated Into A Thermoreversible Hydrogel And Intraperitoneally Administered Result In High Prostate Antitumor Activity And Reduced Cardiotoxicity Of Doxorubicin
Author: Silveira
CP; Apolinario
LM; Favaro
WJ; Paula
AJ; Duran
Abstract: Described here is an anticancer material based on colloidal mesoporous silica nanoparticles (MSNs) functionalized with doxorubicin (DOX), and incorporated into Pluronic F127 hydrogels for prolonged release, with a potential therapeutic application for prostate cancer treatment. The MSNs have spherical morphology, size of about 60 nm, surface area of 970 cm(2) g(-1) and average pore width of 2.0 nm. A high colloidal stability for the MSNs in the physiological medium used for in vivo administration (NaCl 0.9% w/v) could be attained in the presence of PF127 (from 5 to 18 wt %), where depletion repulsion forces prevent MSN agglomeration. By conjugating DOX, MSN and PF127 (18 wt %) in NaCl 0.9%, the hybrid system has a gelation temperature of 21 degrees C, which allowed its in vivo administration in the liquid form and further in situ gelation, generating a drug depot system inside the animals after peritoneal injection. The systems were tested in rats with chemically induced prostate cancer and, after this treatment, histopathological analyses confirmed (i) a reduction in the frequency of aggressive tumors; (ii) that the antitumor effect was dependent on MSN concentration; and most importantly (iii) the reduction of DOX intrinsic cardiotoxicity, indicating that the MSNs play a cardioprotective effect.
Subject: Mesoporous Silica Nanoparticles
Pluronic F-127
Prostate Cancer
Drug Delivery
Citation: Acs Biomaterials Science & Engineering. AMER CHEMICAL SOC, n. 2, n. 7, p. 1190 - 1199.
Rights: fechado
Identifier DOI: 10.1021/acsbiomaterials.6b00241
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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