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Type: Artigo de Periódico
Title: Clinicopathologic Features, Microvessel Density, And Immunohistochemical Expression Of Icam-1 And Vegf In 15 Cases Of Secondary Syphilis With Oral Manifestations
Author: Pires
FR; da Silva
PJS; Natal
RF; Alves
FA; Pinto
CAL; Rumayor
A; Miranda
AMMA; de Almeida
Abstract: Several studies have reported the clinical aspects of oral syphilis, but few papers have considered the involved immunoinflammatory mechanisms. Objective. To analyze the clinicopathologic features and expression of immunoinflammatory and vascular proteins in oral secondary syphilis. Study Design. Fifteen patients with oral secondary syphilis were included; histologic features were analyzed using hematoxylin-eosinestained histologic slides and immunohistochemical reactions were performed against intercellular adhesion molecule 1 (ICAM-1), vascular endothelial growth factor (VEGF), and CD34. Results. Lesions presented as multiple plaques and ulcers mostly located on the tongue, lips, and palate. They were covered by a stratified epithelium of irregular thickness showing exocytosis associated with a subjacent plasma cell infiltrate arranged in perivascular and perineural patterns. ICAM-1 and VEGF were expressed on endothelial cells and leukocytes, and microvessel density was similar on the superficial and deep regions of the connective tissue. Conclusions. Expression of immunoinflammatory and vascular proteins was intense, suggesting their participation on the pathogenesis of oral secondary syphilis.
Subject: Endothelial Growth-factor
Adhesion Molecules
Citation: Oral Surgery, Oral Medicine, Oral Pathology And Oral Radiology. ELSEVIER SCIENCE INC, n. 121, n. 3, p. 274 - 281.
Rights: fechado
Identifier DOI: 10.1016/j.oooo.2015.09.022
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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