Please use this identifier to cite or link to this item:
Type: Artigo de Periódico
Title: Pre-neoplastic Epigenetic Disruption Enhancers In Chronic Inflammation Of Transcriptional
Author: Planello
AC; Singhania
R; Kron
KJ; Bailey
SD; Roulois
D; Lupien
M; Line
SRP; de Souza
AP; De Carvalho
Abstract: Chronic periodontitis (CP) is a chronic inflammatory disease independently associated with higher incidence of oral cavity squamous cell carcinoma (OSCC). However, the molecular mechanism responsible for this increased incidence is unknown. Here we profiled the DNA methylome of CP patients and healthy controls and compared to a large set of OSCC samples from TCGA. We observed a significant overlap between the altered DNA methylation patterns in CP and in OSCC, suggesting an emergence of a pre-neoplastic epigenome in CP. Remarkably, the hypermethylated CpGs in CP were significantly enriched for enhancer elements. This aberrant enhancer methylation is functional and able to disrupt enhancer activity by preventing the binding of chromatin looping factors. This study provides new insights on the molecular mechanisms linking chronic inflammation and tumor predisposition, highlighting the role of epigenetic disruption of transcriptional enhancers.
Subject: Dna Methylation
Chronic Periodontitis
Oral Cavity Squamous Cell Carcinoma
Rights: aberto
Identifier DOI: 10.18632/oncotarget.7513
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000375692900038.pdf4.61 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.