Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320480
Type: Artigo de Periódico
Title: Moderate Exercise Attenuates Lipopolysaccharide-induced Inflammation And Associated Maternal And Fetal Morbidities In Pregnant Rats
Author: Kasawara
KT; Cotechini
T; Macdonald-Goodfellow
SK; Surita
FG; Silva
JLPE; Tayade
C; Othman
M; Ozolins
TRS; Graham
CH
Abstract: Fetal growth restriction (FGR) and coagulopathies are often associated with aberrant maternal inflammation. Moderate-intensity exercise during pregnancy has been shown to increase utero-placental blood flow and to enhance fetal nutrition as well as fetal and placental growth. Furthermore, exercise is known to reduce inflammation. To evaluate the effect of moderate-intensity exercise on inflammation associated with the development of maternal coagulopathies and FGR, Wistar rats were subjected to an exercise regime before and during pregnancy. To model inflammation-induced FGR, pregnant rats were administered daily intraperitoneal injections of E. coli lipopolysaccharide (LPS) on gestational days (GD) 13.5-16.5 and sacrificed at GD 17.5. Control rats were injected with saline. Maternal hemostasis was assessed by thromboelastography. Moderate-intensity exercise prevented LPS-mediated increases in white blood cell counts measured on GD 17.5 and improved maternal hemostasis profiles. Importantly, our data reveal that exercise prevented LPS-induced FGR. Moderate-intensity exercise initiated before and maintained during pregnancy may decrease the severity of maternal and perinatal complications associated with abnormal maternal inflammation.
Subject: Low-dose Endotoxin
Growth Restriction
Periodontal-disease
Physical-activity
Animal-model
Serum-levels
Preeclampsia
Coagulation
Hypertension
Pathophysiology
Editor: PUBLIC LIBRARY SCIENCE
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0154405
Address: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154405
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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