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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de Periódicopt_BR
dc.titleThree New Trixane Glycosides Obtained From The Leaves Of Jungia Sellowii Less. Using Centrifugal Partition Chromatographypt_BR
dc.contributor.authorAzevedopt_BR
dc.contributor.authorL; Faquetipt_BR
dc.contributor.authorL; Kritsanidapt_BR
dc.contributor.authorM; Efstathioupt_BR
dc.contributor.authorA; Smirlispt_BR
dc.contributor.authorD; Franchipt_BR
dc.contributor.authorGC; Genta-Jouvept_BR
dc.contributor.authorG; Michelpt_BR
dc.contributor.authorS; Sandjopt_BR
dc.contributor.authorLP; Grougnetpt_BR
dc.contributor.authorR; Biavattipt_BR
dc.contributor.authorMWpt_BR
unicamp.author.emailraphael.grougnet@parisdescartes.fr; maique.biavatti@ufsc.brpt_BR
dc.subjectCpcpt_BR
dc.subjectGuaianept_BR
dc.subjectJungiapt_BR
dc.subjectTrixanolidept_BR
dc.description.abstractJungia sellowii (Asteraceae) is a shrub that grows in Southern Brazil and polar extract of its leaves presents anti-inflammatory properties. Cyperane, guaiane, nortrixane, and trixane sesquiterpene types were reported as the main metabolites in Jungia species. This work aims to describe the isolation and identification of sesquiterpenes in the leaves of J. sellowii using liquid-liquid partition and centrifugal partition chromatography. Thus, the crude extract of fresh leaves of J. sellowii was partitioned with hexane, dichloromethane, ethyl acetate and butanol, respectively. The butanol fraction was then subjected to a selected ternary system optimized for the CPC (centrifugal partition chromatography): ethyl acetate-ethanol-water (9:2:10, v/v/v). The separation was carried out isocratically at a flow rate of 25 mL/min at 1200 rpm, affording seven fractions A to G. TLC of fractions B, C and F displayed a single spot corresponding to three new glycosylated sesquiterpenoids. Their structures were established by using spectroscopic data in comparison to those reported in the literature. Furthermore, the isolates were evaluated for their leishmanicidal and cytotoxic effects. No cytotoxic effect was observed against the three cancer cell lines (HL60, JURKAT and REH), but compound 1 showed a weak antiprotozoal activity. Liquid-liquid partition and CPC turned to be a versatile technique of glycoside purification which is environmentally friendly and requires a limited amount of organic solvents.en
dc.relation.ispartofBeilstein Journal of Organic Chemistrypt_BR
dc.publisher.cityFRANKFURT AM MAINpt_BR
dc.publisherBEILSTEIN-INSTITUTpt_BR
dc.date.issued2016pt_BR
dc.identifier.citationBeilstein Journal Of Organic Chemistry. BEILSTEIN-INSTITUT, n. 12, p. 674 - 683.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume12pt_BR
dc.description.issuenumberpt_BR
dc.description.firstpage674pt_BR
dc.description.lastpage683pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1860-5397pt_BR
dc.identifier.wosidWOS:000373757600001pt_BR
dc.identifier.doi10.3762/bjoc.12.68pt_BR
dc.identifier.urlhttp://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-12-68pt_BR
dc.description.sponsorshipFP7-PEOPLE-IRSES Marie Curie Actions, program "ChemBioFight'' [269031]pt_BR
dc.date.available2016-12-06T18:32:09Z-
dc.date.accessioned2016-12-06T18:32:09Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T18:32:09Z (GMT). No. of bitstreams: 1 000373757600001.pdf: 858581 bytes, checksum: 30ecdd80f657b18a785385df11a7d191 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320459-
dc.description.conferencelocationpt_BR
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