Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320433
Type: Artigo de Periódico
Title: Influence Of Purified Multiwalled Carbon Nanotubes On The Mechanical And Morphological Behavior In Poly (l-lactic Acid) Matrix
Author: Leal
CV; Martinez
DST; Mas
BA; Alves
OL; Duek
EAR
Abstract: Poly (L-latic acid) (PLLA) is a bioresorbable polymer widely used as a biomaterial, but its fragility can limit its use. An alternative is to produce polymer nanocomposites, which can enhance the mechanical properties of polymeric matrix, resulting in a material with differentiated properties. In this work, PLLA based nanocomposites containing 0.25, 0.5 and 1.0 wt% of purified multiwalled carbon nanotubes (p-MWCNTs) were prepared by the solvent casting method. The morphology and mechanical properties results show an improvement in strain at break for 0.25 and 0.5 wt% p-MWCNTs and an increase in stiffness and elastic modulus for all compositions. Nanocomposites presented a p-MWCNTs agglomeration; however, there was a good stress transfer between PLLA and p-MWCNTs, which was confirmed by the increase in the hardness and elastic modulus. Atomic force microscopy analysis indicated an increase in roughness after nanotube addition. The in vitro biological study showed that PLLA/p-MWCNTs nanocomposites are cytocompatible with osteoblasts cells. The capacity of PLLA nanocomposites to stimulate osteogenesis was investigated by alkaline phosphatase (ALP) activity assay. Higher ALP activity was found on osteoblasts cultured on nanocomposites with 0.25 and 0.5 wt% p-MWCNT compared to neat PLLA, confirming that PLLA cytocompatibility was improved on these compositions. Finally, our results showed that by a simple and inexpensive solvent casting method, it is possible to manufacture biofunctional nanocomposites devices with potential for orthopedic applications. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Poly (l-lactic Acid)
Carbon Nanotubes
Nanocomposites
Cytocompatibility
Toxicity
Editor: ELSEVIER SCIENCE BV
Citation: Journal Of The Mechanical Behavior Of Biomedical Materials. ELSEVIER SCIENCE BV, n. 59, p. 547 - 560.
Rights: fechado
Identifier DOI: 10.1016/j.jmbbm.2016.03.016
Address: http://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S1751616116300364
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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