Please use this identifier to cite or link to this item:
Type: Artigo de Periódico
Title: Detection Of Pup Odors By Non-canonical Adult Vomeronasal Neurons Expressing An Odorant Receptor Gene Is Influenced By Sex And Parenting Status
Author: Nakahara
TS; Cardozo
LM; Ibarra-Soria
X; Bard
AD; Carvalho
VMA; Trintinalia
GZ; Logan
DW; Papes
Abstract: Olfaction is a fundamental sense through which most animals perceive the external world. The olfactory system detects odors via specialized sensory organs such as the main olfactory epithelium and the vomeronasal organ. Sensory neurons in these organs use G-protein coupled receptors to detect chemosensory stimuli. The odorant receptor (OR) family is expressed in sensory neurons of the main olfactory epithelium, while the adult vomeronasal organ is thought to express other types of receptors. Results: Here, we describe Olfr692, a member of the OR gene family identified by next-generation RNA sequencing, which is highly upregulated and non-canonically expressed in the vomeronasal organ. We show that neurons expressing this gene are activated by odors emanating from pups. Surprisingly, activity in Olfr692-positive cells is sexually dimorphic, being very low in females. Our results also show that juvenile odors activate a large number of Olfr692 vomeronasal neurons in virgin males, which is correlated with the display of infanticide behavior.. In contrast, activity substantially decreases in parenting males (fathers), where infanticidal aggressive behavior is not frequently observed. Conclusions: Our results describe, for the first time, a sensory neural population with a specific molecular identity involved in the detection of pup odors. Moreover, it is one of the first reports of a group of sensory neurons the activity of which is sexually dimorphic and depends on social status. Our data suggest that the Olfr692 population is involved in mediating pup-oriented behaviors in mice.
Subject: Olfaction
Odorant Receptor
Pup Odors
Sexual Dimorphism
Social Behavior
Vomeronasal Organ
Citation: Bmc Biology. BIOMED CENTRAL LTD, n. 14, n. 12, p. .
Rights: aberto
Identifier DOI: 10.1186/s12915-016-0234-9
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000370007400001.pdf2.62 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.