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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn1687-6970pt
dc.typeArtigo de Periódicopt_BR
dc.titleEfficacy Of Continuous S(+)-ketamine Infusion For Postoperative Pain Control: A Randomized Placebo-controlled Trialpt_BR
dc.contributor.authorMiziarapt_BR
dc.contributor.authorLEDG; Simonipt_BR
dc.contributor.authorRF; Estevespt_BR
dc.contributor.authorLO; Cangianipt_BR
dc.contributor.authorLH; Grillopt_BR
dc.contributor.authorGFR; Paulapt_BR
dc.contributor.authorAGLEpt_BR
unicamp.author.emailmiziara.luiz@cmcnet.com.brpt_BR
dc.subject:d-aspartate Receptorpt_BR
dc.subjectMu-opioid Receptorpt_BR
dc.subjectDorsal-hornpt_BR
dc.subjectTyrosine Phosphorylationpt_BR
dc.subjectInduced Hyperalgesiapt_BR
dc.subjectRemifentanilpt_BR
dc.subjectKetaminept_BR
dc.subjectTolerancept_BR
dc.subjectHumanspt_BR
dc.subjectPotentiationpt_BR
dc.description.abstractAim. A double-blind, randomized, placebo-controlled trial was designed to evaluate the efficacy of continuous intraoperative infusion of S(+)-ketamine under intravenous anesthesia with target-controlled infusion of remifentanil and propofol for postoperative pain control. Methods. Forty-eight patients undergoing laparoscopic cholecystectomy were assigned to receive continuous S(+)-ketamine infusion at a rate of 0.3mg.kg(-1).h(-1) (n = 24, intervention group) or an equivalent volume of saline at the same rate (n = 24, placebo group). The same target-controlled intravenous anesthesia was induced in both groups. Pain was assessed using a 0 to 10 verbal numeric rating scale during the first 12 postoperative hours. Pain scores and morphine consumption were recorded in the postanesthesia care unit (PACU) and at 4 and 12 hours after surgery. Results. Pain scores were lower in the intervention group at all time points. Morphine consumption did not differ significantly between groups during PACU stay, but it was significantly lower in the intervention group at each time point after PACU discharge (P = 0.0061). At 12 hours after surgery, cumulative morphine consumption was also lower in the intervention group (5.200 +/- 2.707) than in the placebo group (7.525 +/- 1.872). Conclusions. Continuous S(+)-ketamine infusion during laparoscopic cholecystectomy under target-controlled intravenous anesthesia provided better postoperative pain control than placebo, reducing morphine requirement. Trial Registration. This trial is registered with ClinicalTrials.gov NCT02421913.en
dc.relation.ispartofAnesthesiology Research and Practicept_BR
dc.publisher.cityNEW YORKpt_BR
dc.publisherHINDAWI PUBLISHING CORPpt_BR
dc.date.issued2016pt_BR
dc.identifier.citationAnesthesiology Research And Practice. HINDAWI PUBLISHING CORP, n. 6918327, p. .pt_BR
dc.language.isoEnglishpt_BR
dc.description.volumept_BR
dc.description.issuenumberpt_BR
dc.description.lastpagept_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1687-6962pt_BR
dc.identifier.wosidWOS:000370267900001pt_BR
dc.identifier.doi10.1155/2016/6918327pt_BR
dc.identifier.urlhttps://www.hindawi.com/journals/arp/2016/6918327/abs/pt_BR
dc.date.available2016-12-06T18:31:57Z-
dc.date.accessioned2016-12-06T18:31:57Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T18:31:57Z (GMT). No. of bitstreams: 1 000370267900001.pdf: 1368756 bytes, checksum: e3540cf880d0327179e22a123629e1a5 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320415-
dc.description.conferencelocationpt_BR
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