Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320374
Type: Resenha
Title: The Brazilian Amaryllidaceae As A Source Of Acetylcholinesterase Inhibitory Alkaloids
Author: de Andrade
JP; Giordani
RB; Torras-Claveria
L; Pigni
NB; Berkov
S; Font-Bardia
M; Calvet
T; Konrath
E; Bueno
K; Sachett
LG; Dutilh
JH; Borges
WD; Viladomat
F; Henriques
AT; Nair
JJ; Zuanazzi
JAS; Bastida
J
Abstract: Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.
Subject: Galanthamine
Gc-ms
Hippeastrum
Sanguinine
X-ray Crystallography
Editor: SPRINGER
Rights: fechado
Identifier DOI: 10.1007/s11101-015-9411-7
Address: http://link-springer-com.ez88.periodicos.capes.gov.br/article/10.1007%2Fs11101-015-9411-7
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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