Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320230
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn1552-4175pt
dc.typeArtigo de Periódicopt_BR
dc.titleTopical Docosahexaenoic Acid (dha) Accelerates Skin Wound Healing In Rats And Activates Gpr120pt_BR
dc.contributor.authorArantespt_BR
dc.contributor.authorEL; Draganopt_BR
dc.contributor.authorN; Ramalhopt_BR
dc.contributor.authorA; Vitorinopt_BR
dc.contributor.authorD; de-Souzapt_BR
dc.contributor.authorGF; Limapt_BR
dc.contributor.authorMHM; Vellosopt_BR
dc.contributor.authorLA; Araujopt_BR
dc.contributor.authorEPpt_BR
unicamp.author.emailpa.eliana@gmail.compt_BR
dc.subjectGpr120pt_BR
dc.subjectInflammationpt_BR
dc.subjectUnsaturated Fatty Acidpt_BR
dc.subjectTgf-pt_BR
dc.description.abstractThe development of methods for improving skin wound healing may have an impact on the outcomes of a number of medical conditions. The topical use of polyunsaturated fatty acids (PUFAs) can accelerate skin wound healing through mechanisms that involve, at least in part, the modulation of inflammatory activity. Purpose: We evaluated whether G-protein-coupled receptor 120 (GPR120), a recently identified receptor for docosahexaenoic acid (DHA) with anti-inflammatory activity, is expressed in the skin and responds to topical DHA. Method: Male Wistar rats were submitted to an 8.0-mm wound on the back and were immediately administered a topical treatment of a solution containing 30 M of DHA once a day. The healing process was photodocumented, and tissues were collected on Days 5, 9, and 15 for protein and RNA analyses and histological evaluation. Results: GPR120 was expressed in the intact skin and in the wound. Keratinocytes expressed the most skin GPR120, while virtually no expression was detected in fibroblasts. Upon DHA topical treatment, wound healing was significantly accelerated and was accompanied by the molecular activation of GPR120, as determined by its association with -arrestin-2. In addition, DHA promoted a reduction in the expression of interleukin (IL) 1 and an increase in the expression of IL-6. Furthermore, there was a significant increase in expression of transforming growth factor (TGF-) and the keratinocyte marker involucrin. Discussion: Topical DHA improved skin wound healing. The activation of GPR120 is potentially involved in this process.en
dc.relation.ispartofBiological Research for Nursingpt_BR
dc.publisher.cityTHOUSAND OAKSpt_BR
dc.publisherSAGE PUBLICATIONS INCpt_BR
dc.date.issued2016pt_BR
dc.identifier.citationBiological Research For Nursing. SAGE PUBLICATIONS INC, n. 18, n. 4, p. 411 - 419.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume18pt_BR
dc.description.issuenumberpt_BR
dc.description.firstpage411pt_BR
dc.description.lastpage419pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1099-8004pt_BR
dc.identifier.wosidWOS:000378747300006pt_BR
dc.identifier.doi10.1177/1099800415621617pt_BR
dc.identifier.urlhttp://brn.sagepub.com/content/18/4/411.abstractpt_BR
dc.description.sponsorshipSao Paulo Research Foundationpt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2016-12-06T18:31:10Z-
dc.date.accessioned2016-12-06T18:31:10Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T18:31:10Z (GMT). No. of bitstreams: 0 Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320230-
dc.description.conferencelocationpt_BR
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.