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Type: Artigo de Periódico
Title: Pretransplant Beta(2)-microglobulin Is Associated With The Risk Of Acute Graft-versus-host-disease After Allogeneic Hematopoietic Cell Transplant
Author: Costa-Lima
C; Miranda
ECM; Colella
MP; Aranha
FJP; de Souza
CA; Vigorito
AC; De Paula
Abstract: The risk of acute graft-versus-host disease (aGVHD) can be reliably estimated by the hematopoietic cell transplantation-specific comorbidity index (HCT-CI), which can be further refined by the incorporation of pre-hematopoietic cell transplantation (HCT) serum levels of inflammatory biomarkers such as ferritin and albumin. beta(2)-Microglobulin (beta(2)-m) is a key component of the MHC class I complex, which is independently associated with mortality and frailty in the general population. We took advantage of our institutional protocol that includes measurement of pre-HCT beta(2)-m serum levels in the most patients to investigate whether pre-transplant beta(2)-m levels were associated with the risk of aGVHD. One hundred three consecutive patients submitted to allogeneic HCT, of which 26 developed grades II to IV aGVHD, were included in the analysis. beta(2)-m was significantly associated with age and HCT-CI. Higher levels of beta(2)-m were observed in patients who developed aGVHD (P = .008). In the multivariate Cox regression model, beta(2)-m and HCT-CI remained independently associated with the risk of developing aGVHD. In conclusion, the association between beta(2)-m and the occurrence of aGVHD suggests that the measurement of this protein before HCT might represent an additional element for risk stratification of aGVHD. (C) 2016 American Society for Blood and Marrow Transplantation.
Subject: Beta(2)-microglobulin
Acute Graft-versus-host-disease
Citation: Biology Of Blood And Marrow Transplantation. ELSEVIER SCIENCE INC, n. 22, n. 7, p. 1329 - 1332.
Rights: fechado
Identifier DOI: 10.1016/j.bbmt.2016.03.024
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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