Please use this identifier to cite or link to this item:
Type: Artigo de Periódico
Title: Translation, Cross-cultural Adaptation, And Validation Of The Lee Chronic Graft-versus-host Disease Symptom Scale In A Brazilian Population
Author: de Souza
CV; Vigorito
AC; Miranda
ECM; Garcia
C; Colturato
VAR; Mauad
MA; Moreira
MCR; Bouzas
LFD; Lermontov
S; Hamerschlak
N; Rodrigues
M; Barros
JCD; Chiattone
R; Lee
SJ; Flowers
Abstract: The Lee Chronic Graft-versus-Host Disease (GVHD) Symptom Scale is a patient-reported instrument developed and validated in English to measure the symptoms and functional impact of cGVHD. This tool has not yet been validated in a Latin American population, however. The Brazil-Seattle Chronic GVHD Consortium conducted a multicenter study at 5 Brazilian institutions to validate the Lee cGVHD Symptom Scale in adults with cGVHD. Study objectives included the translation and validation of the instrument in Brazilian Portuguese and evaluation of the correlation with other quality of life (QoL) tools, including the Medical Outcomes Study Short Form 36 (SF-36) and Functional Assessment of Chronic Illness Therapy with Bone Marrow Transplant subscale (FACT-BMT). Translation and validation were done according to the American Association of Orthopedic Surgeons Outcome Committee guidelines. Spearman's correlation coefficient was used to measure construct validity. Reliability was assessed using Cronbach's alpha and intraclass correlation coefficients. Between April 2011 and August 2012, 47 patients with cGVHD based on the 2005 National Institutes of Health criteria (29 males [62%], 18 females [38%]; median age, 48 years; range, 23 to 69 years) were enrolled in this study. The reliability of the Lee cGVHD Symptom Scale was adequate (Cronbach's alpha = 0.62 to 0.83). The correlations between similar domains of the Lee cGVHD Symptom Scale, SF-36, and FACT-BMT were moderate to high. Our data indicate that the Brazilian Portuguese version of the Lee cGVHD Symptom Scale is valid and reliable and can be used in clinical trials of cGVHD in Brazil. (C) 2016 American Society for Blood and Marrow Transplantation.
Subject: Chronic Graft-versus-host Disease
Lee Chronic Graft-versus-host
Disease Symptom Scale
Patient-reported Symptoms
Allogeneic Hematopoietic Cell Transplantation
Citation: Biology Of Blood And Marrow Transplantation. ELSEVIER SCIENCE INC, n. 22, n. 7, p. 1313 - 1318.
Rights: fechado
Identifier DOI: 10.1016/j.bbmt.2016.03.013
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000378462700024.pdf6.48 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.