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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn1600-0897pt
dc.typeArtigo de Periódicopt_BR
dc.titleVaginal Inflammation: Association Between Leukocyte Concentration And Levels Of Immune Mediatorspt_BR
dc.contributor.authorBeghinipt_BR
dc.contributor.authorJ; Giraldopt_BR
dc.contributor.authorPC; Eleuteriopt_BR
dc.contributor.authorJ; do Amaralpt_BR
dc.contributor.authorRL; Polpetapt_BR
dc.contributor.authorNC; Goncalvespt_BR
dc.contributor.authorAKpt_BR
unicamp.author.emailjozibeghini@yahoo.com.brpt_BR
dc.subjectBeta-defensinpt_BR
dc.subjectExtracellular Matrix Metalloproteinase Inducer (emmprin)pt_BR
dc.subjectHyaluronanpt_BR
dc.subjectInflammationpt_BR
dc.subjectLeukocytespt_BR
dc.subjectMatrix Metalloproteinase-8 (mmp-8)pt_BR
dc.subjectNeutrophil Gelatinase-associated Lipocalin (ngal)pt_BR
dc.description.abstractProblem A wide variety of mediators are involved in inflammatory processes. However, the identity of those participating in vaginal immune responses has not been established. We correlated extracellular matrix metalloproteinase inducer (EMMPRIN), matrix metalloproteinase-8 (MMP-8), hyaluronan (HA), hyaluronidase-1 (Hyal-1), human beta-defensin-2 (hBD2), and neutrophil gelatinase-associated lipocalin (NGAL) concentrations with the extent of leukocyte infiltration into the vagina and suggest their participation in vaginal inflammation. Methods of study Vaginal fluid was obtained from 233 women seen at the outpatient clinic in the Department of Obstetrics and Gynecology at Campinas University, Brazil. The magnitude of vaginal inflammation was determined by the leukocyte count on vaginal smears and categorized as no inflammation (0 leukocytes/field), moderate inflammation (1-4 leukocytes/field), and intense inflammation (>4 leukocytes/field). Concentrations of EMMPRIN, MMP-8, HA, Hyal-1, hBD2, and NGAL were determined in vaginal fluid by ELISA. Results EMMPRIN, MMP-8, HA, hBD2, and NGAL concentration increased with elevated leukocyte numbers (P < 0.05), while Hyal-1 did not. EMMPRIN concentrations were correlated with HA and MMP-8 levels. Conclusion EMMPRIN, MMP-8, HA, b-defensin, and NGAL are elevated in women with vaginal inflammation.en
dc.relation.ispartofAmerican Journal of Reproductive Immunologypt_BR
dc.publisher.cityHOBOKENpt_BR
dc.publisherWILEY-BLACKWELLpt_BR
dc.date.issued2016pt_BR
dc.identifier.citationAmerican Journal Of Reproductive Immunology. WILEY-BLACKWELL, n. 75, n. 2, p. 126 - 133.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume75pt_BR
dc.description.issuenumberpt_BR
dc.description.firstpage126pt_BR
dc.description.lastpage133pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1046-7408pt_BR
dc.identifier.wosidWOS:000370157900006pt_BR
dc.identifier.doi10.1111/aji.12475pt_BR
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aji.12475/abstractpt_BR
dc.description.sponsorshipResearch Support Foundation of Sao Paulo (FAPESP) [2011/19960-9]pt_BR
dc.description.sponsorshipCAPES [4889-13-14]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2016-12-06T18:30:58Z-
dc.date.accessioned2016-12-06T18:30:58Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T18:30:58Z (GMT). No. of bitstreams: 1 000370157900006.pdf: 209469 bytes, checksum: 3760c44f3e24420f4bde774ded0b0f3c (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320182-
dc.description.conferencelocationpt_BR
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