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Type: Artigo de Periódico
Title: Brief Timelapse On Dendrimer Chemistry: Advances, Limitations, And Expectations
Author: Ornelas
Abstract: Dendrimers are well-defined branched macromolecules that have been studied for a wide variety of applications. Possibility to add multiple functionalities in precise locations of the dendritic structure generated great expectations for the application of dendrimers in nanomedicine, however, the number of dendrimer-based formulations that advance to clinical studies has been somewhat deceiving. This is partially due to the nonreproducible pharmokinetic behavior observed for multifunctional dendrimers synthesized through the random-statistical approach that leads to mixtures of products. Therefore, it is crucial to develop multifunctional dendrimers with well-defined structures in order to increase the chances of meeting the clinical expectations placed on dendrimers. This talent article will give an overview of the dendrimer field, discussing the application of dendrimers in nanomedicine, light-harvesting systems, sensing and catalysis, with a critical analysis on the expectations, limitations, advances, current challenges and future directions.
Subject: Dendrimers
Citation: Macromolecular Chemistry And Physics. WILEY-V C H VERLAG GMBH, n. 217, n. 2, p. 149 - 174.
Rights: fechado
Identifier DOI: 10.1002/macp.201500393
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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