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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn1873-4847pt
dc.typeArtigo de Periódicopt_BR
dc.titleDietary Interesterified Fat Enriched With Palmitic Acid Induces Atherosclerosis By Impairing Macrophage Cholesterol Efflux And Eliciting Inflammationpt_BR
dc.contributor.authorAfonsopt_BR
dc.contributor.authorMS; Lavradorpt_BR
dc.contributor.authorMSF; Koikept_BR
dc.contributor.authorMK; Cintrapt_BR
dc.contributor.authorDE; Ferreirapt_BR
dc.contributor.authorFD; Nunespt_BR
dc.contributor.authorVS; Castilhopt_BR
dc.contributor.authorG; Gioiellipt_BR
dc.contributor.authorLA; Bombopt_BR
dc.contributor.authorRP; Catanozipt_BR
dc.contributor.authorS; Caldinipt_BR
dc.contributor.authorEG; Damaceno-Rodriguespt_BR
dc.contributor.authorNR; Passarellipt_BR
dc.contributor.authorM; Nakandakarept_BR
dc.contributor.authorER; Lottenbergpt_BR
dc.contributor.authorAMpt_BR
unicamp.author.emailmilessafonso@gmail.com; mariasilviaferrari@yahoo.com.br; mkoike2011@gmail.com; dcintra@yahoo.com; fabianaferreira1@hotmail.com; valeriasutti@gmail.com; ga.castilho@gmail.com; lagio@usp.br; rebombo@terra.com.br; catanozi@usp.br; elia@usp.br; nilsa@usp.br; mpassere@usp.br; enakonda@usp.br; ana.lottenberg@hc.fm.usp.brpt_BR
dc.subjectAtherosclerosispt_BR
dc.subjectInteresterified Fatpt_BR
dc.subjectTrans Fatpt_BR
dc.subjectDietpt_BR
dc.subjectLipoprotein Metabolismpt_BR
dc.subjectMicept_BR
dc.description.abstractInteresterified fats are currently being used to replace trans fatty acids. However, their impact on biological pathways involved in the atherosclerosis development was not investigated. Weaning male LDLr-KO mice were fed for 16 weeks on a high-fat diet (40% energy as fat) containing polyunsaturated (PUFA), TRANS, palmitic (PALM), palmitic interesterified (PALM INTER), stearic (STEAR) or stearic interesterified (STEAR INTER). Plasma lipids, lipoprotein profile, arterial lesion area, macrophage infiltration, collagen content and inflammatory response modulation were determined. Macrophage cholesterol efflux and the arterial expression of cholesterol uptake and efflux receptors were also performed. The interesterification process did not alter plasma lipid concentrations. Although PALM INTER did not increase plasma cholesterol concentration as much as TRANS, the cholesterol enrichment in the LDL particle was similar in both groups. Moreover, PALM INTER induced the highest IL-1 beta, MCP-1 and IL-6 secretion from peritoneal macrophages as compared to others. This inflammatory response elicited by PALM INTER was confirmed in arterial wall, as compared to PALM. These deleterious effects of PALM INTER culminate in higher atherosclerotic lesion, macrophage infiltration and collagen content than PALM, STEAR, STEAR INTER and PUFA. These events can partially be attributed to a macrophage cholesterol accumulation, promoted by apoAl and HDL2-mediated cholesterol efflux impairment and increased Olr-1 and decreased Abca1 and Nr1h3 expressions in the arterial wall. Interesterified fats containing palmitic acid induce atherosclerosis development by promoting cholesterol accumulation in LDL particles and macrophagic cells, activating the inflammatory process in LDLr-KO mice. (C) 2016 Elsevier Inc. All rights reserved.en
dc.relation.ispartofThe Journal of Nutritional Biochemistrypt_BR
dc.publisher.cityNEW YORKpt_BR
dc.publisherELSEVIER SCIENCE INCpt_BR
dc.date.issued2016pt_BR
dc.identifier.citationThe Journal Of Nutritional Biochemistry. ELSEVIER SCIENCE INC, n. 32, p. 91 - 100.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume32pt_BR
dc.description.issuenumberpt_BR
dc.description.firstpage91pt_BR
dc.description.lastpage100pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0955-2863pt_BR
dc.identifier.wosidWOS:000377634300010pt_BR
dc.identifier.doi10.1016/j.jnutbio.2016.01.005pt_BR
dc.identifier.urlhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S095528631600036Xpt_BR
dc.description.sponsorshipState of Sao Paulo Research Foundation (FAPESP) [11/50443-0, 12/50249-2]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2016-12-06T18:30:47Z-
dc.date.accessioned2016-12-06T18:30:47Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T18:30:47Z (GMT). No. of bitstreams: 1 000377634300010.pdf: 1546470 bytes, checksum: 49ebf68d90d8c4adce003d383b024fc3 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320125-
dc.description.conferencelocationpt_BR
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