Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320122
Type: Artigo
Title: The role of endogenous opioid peptides in the antinociceptive effect of 15-deoxy (delta 12,14)-prostaglandin J(2) in the temporomandibular joint
Author: Macedo, C. G.
Napimoga, M. H.
Rocha-Neto, L. M.
Abdalla, H. B.
Clemente-Napimoga, J. T.
Abstract: We have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect. (C) 2016 Elsevier Ltd. All rights reserved.
We have previously demonstrated that peripheral administration of 15d-PGJ(2) in the Temporomandibular joint (TMJ) of rats can prevent nociceptor sensitization, mediated by peroxisome proliferator activated receptor-gamma (PPAR-gamma), and kappa- and delta- opioid receptors. However, the mechanism that underlies the signaling of PPAR-gamma (upon activation by 15d-PGJ(2)) to induce antinociception, and how the opioid receptors are activated via 15d-PGJ(2) are not fully understood. This study demonstrates that peripheral antinociceptive effect of 15d-PGJ(2) is mediated by PPAR-gamma expressed in the inflammatory cells of TMJ tissues. Once activated by 15d-PGJ(2), PPAR-gamma induces the release of beta-endorphin and dynorphin, which activates kappa- and delta-opioid receptors in primary sensory neurons to induce the antinociceptive effect
Subject: Articulação temporomandibular
Country: Reino Unido
Editor: Churchill Livingstone/Elsevier
Citation: Prostaglandins, Leukotrienes And Essential Fatty Acids (plefa). ELSEVIER SCI LTD, n. 110, p. 27 - 34.
Rights: fechado
Identifier DOI: 10.1016/j.plefa.2016.05.009
Address: https://www.sciencedirect.com/science/article/pii/S095232781530065X?via%3Dihub
Date Issue: 2016
Appears in Collections:FOP - Artigos e Outros Documentos

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