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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.identifier.isbn1600-0714pt
dc.typeResenhapt_BR
dc.titleMolecular Signature Of Salivary Gland Tumors: Potential Use As Diagnostic And Prognostic Markerpt_BR
dc.contributor.authorFonsecapt_BR
dc.contributor.authorFP; Senapt_BR
dc.contributor.authorM; Altemanipt_BR
dc.contributor.authorA; Speightpt_BR
dc.contributor.authorPM; Vargaspt_BR
dc.contributor.authorPApt_BR
unicamp.author.emailpavargas@fop.unicamp.brpt_BR
dc.subjectCrtc1-maml2pt_BR
dc.subjectEtv6-ntrk3pt_BR
dc.subjectEwsr1-atf1pt_BR
dc.subjectMyb-nfibpt_BR
dc.subjectSalivary Gland Tumorpt_BR
dc.description.abstractSalivary gland tumors are a highly heterogeneous group of lesions with diverse microscopic appearances and variable clinical behavior. The use of clinical and histological parameters to predict patient prognosis and survival rates has been of limited utility, and the search for new biomarkers that could not only aid in a better understanding of their pathogenesis but also be reliable auxiliaries for prognostic determination and useful diagnostic tools has been performed in the last decades with very exciting results. Hence, gene rearrangements such as CRTC1-MAML2 in mucoepidermoid carcinomas have shown excellent specificity, and more than that, it has been strongly correlated with low-grade tumors and consequently with an increased survival rate and better prognosis of patients affected by neoplasms carrying this translocation. Moreover, MYB-NFIB and EWSR1-ATF1 gene fusions were shown to be specifically found in cases of adenoid cystic carcinomas and hyalinizing clear cell carcinomas, respectively, in the context of salivary gland tumors, becoming reliable diagnostic tools for these entities and potential therapeutic targets for future therapeutic protocols. Finally, the identification of ETV6-NTRK3 in cases previously diagnosed as uncommon acinic cell carcinomas, cystadenocarcinomas, and adenocarcinomas not otherwise specified led to the characterization of a completely new and now widely accepted entity, including, therefore, mammary analogue secretory carcinoma in the list of well-recognized salivary gland carcinomas. Thus, further molecular investigations of salivary gland tumors are warranted, and the recognition of other genetic abnormalities can lead to the acknowledgment of new entities and the acquirement of reliable biomarkers.en
dc.relation.ispartofJournal of Oral Pathology & Medicinept_BR
dc.publisher.cityHOBOKENpt_BR
dc.publisherWILEY-BLACKWELLpt_BR
dc.date.issued2016pt_BR
dc.identifier.citationJournal Of Oral Pathology & Medicine. WILEY-BLACKWELL, n. 45, n. 2, p. 101 - 110.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume45pt_BR
dc.description.issuenumberpt_BR
dc.description.firstpage101pt_BR
dc.description.lastpage110pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0904-2512pt_BR
dc.identifier.wosidWOS:000369988600005pt_BR
dc.identifier.doi10.1111/jop.12329pt_BR
dc.identifier.urlhttp://onlinelibrary-wiley-com.ez88.periodicos.capes.gov.br/doi/10.1111/jop.12329/abstractpt_BR
dc.description.sponsorshipSao Paulo State Research Foundation (Brazil) [2012/07519-9, 2012/10781-7, 2013/15955-6]pt_BR
dc.description.sponsorshipBrazilian Coordination of Higher Education [CAPES/PDSE 2892/13-8]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2016-12-06T18:30:37Z-
dc.date.accessioned2016-12-06T18:30:37Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T18:30:37Z (GMT). No. of bitstreams: 1 000369988600005.pdf: 1394238 bytes, checksum: 0cb61dfe9979bc38f808e8f88f3a4db3 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/320078-
dc.description.conferencelocationpt_BR
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