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Type: Artigo de Periódico
Title: Association Of Mineralocorticoid Receptor Polymorphism I180v With Left Ventricular Hypertrophy In Resistant Hypertension
Author: Ritter
AMV; Fontana
V; de Faria
APC; Modolo
R; Barbaro
NR; Sabbatini
AR; Peres
H; Biagi
C; Silva
PS; Lopes
PC; Tanus-Santos
JE; Coelho
EB; Moreno
Abstract: Genetic polymorphisms on mineralocorticoid receptor gene (NC3C2) are associated with variability of mineralocorticoid receptor (MR) function and cardiovascular implications. We sought to investigate whether I180V (rs5522) and MRc.-2G_C (rs2070951) polymorphisms in NR3C2 gene are associated with resistance to antihypertensive treatment and target-organ damage in resistant hypertensive (RHTN) patients. METHODS One hundred and eighty-one RHTN and 122 mild to moderate hypertensive (HTN) patients were enrolled in this study. Genotypes were obtained by allelic discrimination assay using real-time polymerase chain reaction. We determined pulse wave velocity (PWV), microalbuminuria, and left ventricular mass index to assess target-organ damage. We compared clinical and laboratorial characteristics of AA vs. G carriers for rs5522 and AC vs. GG vs. CG for rs2070951. RESULTS We did not found differences in allele, genotype, and haplotype frequencies for both polymorphisms between HTN and RHTN subjects. We found increased levels of aldosterone and ambulatory blood pressure (BP) in G carriers only for rs5522. Left ventricular hypertrophy (LVH) was more prevalent in G carriers than AA homozygous for rs5522 but not for rs2070951 in RHTN. On the other hand, microalbuminuria and PWV were similar among genotypes for both polymorphisms. No differences were observed between the haplotypes, except for higher aldosterone concentration in GG compared to AG and AC haplotypes. CONCLUSION Our study suggests that rs5522 polymorphism might affect cardiac remodeling and aldosterone levels in RHTN subjects.
Subject: Aldosterone
Blood Pressure
Mineralocorticoid Receptor
Refractory Hypertension
Target-organ Damage
Citation: American Journal Of Hypertension. OXFORD UNIV PRESS, n. 29, n. 2, p. 245 - 250.
Rights: fechado
Identifier DOI: 10.1093/ajh/hpv070
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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