Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320058
Type: Artigo de Periódico
Title: Modulation Of Candida Albicans Virulence By Bacterial Biofilms On Titanium Surfaces
Author: Cavalcanti
YW; Wilson
M; Lewis
M; Del-Bel-Cury
AA; da Silva
WJ; Williams
DW
Abstract: Whilst Candida albicans occurs in peri-implant biofilms, its role in peri-implantitis remains unclear. This study therefore examined the virulence of C. albicans in mixed-species biofilms on titanium surfaces. Biofilms of C. albicans (Ca), C. albicans with streptococci (Streptococcus sanguinis, S. mutans) (Ca-Ss-Sm) and those incorporating Porphyromonas gingivalis (Ca-Pg and Ca-Ss-Sm-Pg) were developed. Expression of C. albicans genes associated with adhesion (ALS1, ALS3, HWP1) and hydrolytic enzymes (SAP2, SAP4, SAP6, PLD1) was measured and hyphal production by C. albicans quantified. Compared with Ca biofilms, significant (p<0.05) up-regulation of ALS3, HWP1, SAP2 and SAP6, and hyphal production occurred in biofilms containing streptococci (Ca-Ss-Sm). In Ca-Pg biofilms, down-regulation of HWP1 and SAP4 expression, with reduced hyphal production occurred. Ca-Ss-Sm-Pg biofilms had increased hyphal proportions and up-regulation of ALS3, SAP2 and SAP6. In conclusion, C. albicans expressed virulence factors in biofilms that could contribute to peri-implantitis, but this was dependent on associated bacterial species.
Subject: Biofilms
Candida
Infection Models
Streptococcus
Porphyromonas
Peri-implantitis
Editor: TAYLOR & FRANCIS LTD
Rights: fechado
Identifier DOI: 10.1080/08927014.2015.1125472
Address: http://www.tandfonline.com/doi/full/10.1080/08927014.2015.1125472
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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