Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/320027
Type: Artigo de Periódico
Title: N-3 Fatty Acids Induce Neurogenesis Of Predominantly Pomc-expressing Cells In The Hypothalamus
Author: Nascimento
LFR; Souza
GFP; Morari
J; Barbosa
GO; Solon
C; Moura
RF; Victorio
SC; Ignacio-Souza
LM; Razolli
DS; Carvalho
HF; Velloso
LA
Abstract: Apoptosis of hypothalamic neurons is believed to play an important role in the development and perpetuation of obesity. Similar to the hippocampus, the hypothalamus presents constitutive and stimulated neurogenesis, suggesting that obesity-associated hypothalamic dysfunction can be repaired. Here, we explored the hypothesis that n-3 polyunsaturated fatty acids (PUFAs) induce hypothalamic neurogenesis. Both in the diet and injected directly into the hypothalamus, PUFAs were capable of increasing hypothalamic neurogenesis to levels similar or superior to the effect of brain-derived neurotrophic factor (BDNF). Most of the neurogenic activity induced by PUFAs resulted in increased numbers of proopiomelanocortin but not NPY neurons and was accompanied by increased expression of BDNF and G-protein-coupled receptor 40 (GPR40). The inhibition of GPR40 was capable of reducing the neurogenic effect of a PUFA, while the inhibition of BDNF resulted in the reduction of global hypothalamic cell. Thus, PUFAs emerge as a potential dietary approach to correct obesity-associated hypothalamic neuronal loss.
Editor: AMER DIABETES ASSOC
Citation: Diabetes. AMER DIABETES ASSOC, n. 65, n. 3, p. 673 - 686.
Rights: fechado
Identifier DOI: 10.2337/db15-0008
Address: http://diabetes.diabetesjournals.org/content/65/3/673.long
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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