Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/319815
Type: Resenha
Title: Phage Display And Shiga Toxin Neutralizers
Author: Bernedo-Navarro
RA; Yano
T
Abstract: The current work presents an overview of the use of phage display technology for the identification and characterization of potential neutralizing agents for Shiga toxins. The last major Shiga toxin-associated disease outbreak, which took place in Germany in 2011, showed the international community that Shiga toxins remain a serious threat to public health. This is also demonstrated by the lack of specific therapies against Shiga toxin-induced Hemolytic Uremic Syndrome (HUS). Since its inception, phage display technology has played a key role in the development of antigen-specific (poly)-peptides or antibody fragments with specific biological properties. Herein, we review the current literature regarding the application of phage display to identify novel neutralizing agents against Shiga toxins. We also briefly highlight reported discoveries of peptides and heavy chain antibodies (VHH fragments or nanobodies) that can neutralize the cellular damage caused by these potent toxins. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Escherichia Coli
Stec
Shiga Toxins
Phage Display
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2016.02.009
Address: http://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0041010116300277
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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