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Type: Artigo de Periódico
Title: Zika Virus Impairs Growth In Human Neurospheres And Brain Organoids
Author: Garcez
PP; Loiola
EC; Da Costa
RM; Higa
LM; Trindade
P; Delvecchio
R; Nascimento
JM; Brindeiro
R; Tanuri
A; Rehen
Abstract: Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development.
Rights: fechado
Identifier DOI: 10.1126/science.aaf6116
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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