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Type: Artigo de periódico
Title: Synthesis And Biological Activity Of Borneol Esters
Abstract: Borneol derivatives have been regarded as promising anti-inflammatory and antimicrobial agents. In this work, eight borneol esters (1-8) were synthesized using DIC/DMAP or SOCl2 method and the products characterized by means of spectroscopic techniques. Six of them are new compounds and the DIC/DMAP method was faster and resulted in high reaction yields. Compounds 1-8 were subjected to in vitro antiproliferative assay using normal and tumor human cell lines and to antioedematogenic activity evaluation. Compound 6 [(1S, 2R, 4S)-1, 7, 7-trimethylbicyclo[2.2.1]heptan-2-yl 3, 4, 5-trimethoxybenzoate] presented a promisor cytotoxic activity against various tumor cell lines and 7 [(1S, 2R, 4S)-1, 7, 7-trimethylbicyclo[2.2.1]heptan-2-yl benzoate] was effective in the reduction of oedematogenic response in all period of time evaluated.
Editor: Secretaria Regional do Rio de Janeiro da Sociedade Brasileira de Quimica
Rights: aberto
Identifier DOI: 10.5935/1984-6835.20160073
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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