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|Type:||Artigo de periódico|
|Title:||Malignancy Risk In Brazilian Women With Endometrial Polyps|
|Abstract:||Background: Endometrial polyps are generally benign, but can turn into premalignant or malignant lesions. Advanced age, menopausal status, abnormal uterine bleeding, polyp size, obesity, hypertension, diabetes, hormone therapy, breast cancer, and tamoxifen use are risk factors. Objective: The aim of this study was to determine the prevalence of malignant lesions on endometrial polyps with resection by hysteroscopy in both pre- and postmenopausal women, and risk factors for malignant transformation. Materials and Methods: This was a retrospective study with 303 women who underwent hysteroscopy-guided polypectomy in 2012 at the hospital of the University of Campinas (UNICAMP), Brazil. Polyps were classified as either benign or malignant. The variables analyzed were age, parity, body mass index, symptoms (asymptomatic, bleeding) associated pathologies (arterial hypertension, diabetes mellitus, breast cancer), endometrial line, and size of the polyp. Frequency, medians, and standard deviation of the study variables were obtained and risk factors for malignant transformation were subjected to multivariate analysis with the odds ratio (OR) adjusted to a 95% confidence interval. Results: Women had a median age of 58 ± 11 years, were 9.6 ± 8.5 years' old since menopause. Histopathologic analyses showed 6% of malignant and premalignant lesions. Risk factors associated with malignancy were age >60 (OR: 2.2; confidence interval [CI] 95%: 1.05-4.71) and postmenopausal bleeding (OR: 4.0; CI95%: 1.92-8.44). Multiparity appeared to be a protective factor (OR: 0.3; CI95%: 0.16-0.70). Conclusions: The malignancy transformation in endometrial polyps rate was low. Risk factors associated were postmenopausal bleeding and advanced age. Multiparity was the protective factor found. Copyright © 2016 Mary Ann Liebert, Inc.|
|Editor:||Mary Ann Liebert Inc.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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