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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleGenome-wide Copy Number Variation (cnv) Detection In Nelore Cattle Reveals Highly Frequent Variants In Genome Regions Harboring Qtls Affecting Production Traitspt_BR
unicamp.author.emailpirovanicp@gmail.compt_BR
unicamp.authorSantiago, A.D.S., Centro de Biologia Molecular e Engenharia Genética (CBMEG), Universidade Estadual de Campinas, Campinas, SP, Brazilpt_BR
unicamp.author.externalMares, J.H., Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazilpt
unicamp.author.externalGramacho, K.P., Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil, Centro de Pesquisas Do Cacau - CEPEC, Comissão Executiva Do Plano da Lavoura Cacaueira- CEPLAC, Ilhéus, Bahia, Brazilpt
unicamp.author.externalDos Santos, E.C., Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazilpt
unicamp.author.externalSilva, E.M.D.A., Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazilpt
unicamp.author.externalAlvim, F.C., Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazilpt
unicamp.author.externalPirovani, C.P., Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazilpt
dc.description.abstractBackground: Copy number variations (CNVs) have been shown to account for substantial portions of observed genomic variation and have been associated with qualitative and quantitative traits and the onset of disease in a number of species. Information from high-resolution studies to detect, characterize and estimate population-specific variant frequencies will facilitate the incorporation of CNVs in genomic studies to identify genes affecting traits of importance. Results: Genome-wide CNVs were detected in high-density single nucleotide polymorphism (SNP) genotyping data from 1,717 Nelore (Bos indicus) cattle, and in NGS data from eight key ancestral bulls. A total of 68,007 and 12,786 distinct CNVs were observed, respectively. Cross-comparisons of results obtained for the eight resequenced animals revealed that 92 % of the CNVs were observed in both datasets, while 62 % of all detected CNVs were observed to overlap with previously validated cattle copy number variant regions (CNVRs). Observed CNVs were used for obtaining breed-specific CNV frequencies and identification of CNVRs, which were subsequently used for gene annotation. A total of 688 of the detected CNVRs were observed to overlap with 286 non-redundant QTLs associated with important production traits in cattle. All of 34 CNVs previously reported to be associated with milk production traits in Holsteins were also observed in Nelore cattle. Comparisons of estimated frequencies of these CNVs in the two breeds revealed 14, 13, 6 and 14 regions in high (>20 %), low (<20 %) and divergent (NEL > HOL, NEL < HOL) frequencies, respectively. Conclusions: Obtained results significantly enriched the bovine CNV map and enabled the identification of variants that are potentially associated with traits under selection in Nelore cattle, particularly in genome regions harboring QTLs affecting production traits. © 2016 The Author(s).en
dc.relation.ispartofBMC Genomicspt_BR
dc.publisherBioMed Central Ltd.pt_BR
dc.date.issued2016pt_BR
dc.identifier.citationBmc Genomics. Biomed Central Ltd., v. 17, p. , 2016.pt_BR
dc.language.isoenpt_BR
dc.description.volume17pt_BR
dc.description.issuenumberpt_BR
dc.description.lastpagept_BR
dc.rightsabertopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn14712164pt_BR
dc.identifier.doi10.1186/s12864-016-2752-9pt_BR
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84978080533&partnerID=40&md5=fd68a25a689802b3d7586880a221e272pt_BR
dc.description.sponsorship578592/2008-8, CNPq, Conselho Nacional de Desenvolvimento Científico e Tecnológicopt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2016-12-06T17:43:31Z-
dc.date.accessioned2016-12-06T17:43:31Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T17:43:31Z (GMT). No. of bitstreams: 1 2-s2.0-84978080533.pdf: 2790481 bytes, checksum: 42e53c52f4941f79ace5fc3a18b2148d (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/319324-
dc.identifier.idScopus2-s2.0-84978080533pt_BR
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