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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSur1 Receptor Interaction With Hesperidin And Linarin Predicts Possible Mechanisms Of Action Of Valeriana Officinalis In Parkinsonpt_BR
unicamp.author.emailferanibal@yahoo.compt_BR
unicamp.authorAllegretti, S.M., Departamento De Biologia Animal, Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazilpt_BR
unicamp.author.externalZaia, M.G., Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos, São Carlos, Brazilpt
unicamp.author.externalCagnazzo, T.O., Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos, São Carlos, Brazilpt
unicamp.author.externalFeitosa, K.A., Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos, São Carlos, Brazilpt
unicamp.author.externalSoares, E.G., Department of Patology, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazilpt
unicamp.author.externalFaccioli, L.H., Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, Brazilpt
unicamp.author.externalAfonso, A., Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos, São Carlos, Brazil, Medical Parasitology Unit, Universidade Nova de Lisboa, Global Health and Tropical Medicine, Instituto de Higiene e Medicina Tropical, Lisbon, Portugal, Bioanalytical, Microfabrication and Separations Group, Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, Brazilpt
unicamp.author.externalAnibal, F.F., Laboratory of Parasitology, Department of Morphology and Pathology, Universidade Federal de São Carlos, São Carlos, Brazilpt
dc.description.abstractParkinson's disease (PD) is one of the most common neurodegenerative disorders. A theoretical approach of our previous experiments reporting the cytoprotective effects of the Valeriana officinalis compounds extract for PD is suggested. In addiction to considering the PD as a result of mitochondrial metabolic imbalance and oxidative stress, such as in our previous in vitro model of rotenone, in the present manuscript we added a genomic approach to evaluate the possible underlying mechanisms of the effect of the plant extract. Microarray of substantia nigra (SN) genome obtained from Allen Brain Institute was analyzed using gene set enrichment analysis to build a network of hub genes implicated in PD. Proteins transcribed from hub genes and their ligands selected by search ensemble approach algorithm were subjected to molecular docking studies, as well as 20 ns Molecular Dynamics (MD) using a Molecular Mechanic Poison/Boltzman Surface Area (MMPBSA) protocol. Our results bring a new approach to Valeriana officinalis extract, and suggest that hesperidin, and probably linarin are able to relieve effects of oxidative stress during ATP depletion due to its ability to binding SUR1. In addition, the key role of valerenic acid and apigenin is possibly related to prevent cortical hyperexcitation by inducing neuronal cells from SN to release GABA on brain stem. Thus, under hyperexcitability, oxidative stress, asphyxia and/or ATP depletion, Valeriana officinalis may trigger different mechanisms to provide neuronal cell protection. © 2016 Santos, Giraldez-Alvarez, ávila-Rodriguez, Capani, Galembeck, Neto, Barreto and Andrade.en
dc.relation.ispartofFrontiers in Aging Neurosciencept_BR
dc.publisherFrontiers Research Foundationpt_BR
dc.date.issued2016pt_BR
dc.identifier.citationFrontiers In Aging Neuroscience. Frontiers Research Foundation, v. 8, p. , 2016.pt_BR
dc.language.isoenpt_BR
dc.description.volume8pt_BR
dc.description.issuenumberpt_BR
dc.description.lastpagept_BR
dc.rightsabertopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn16634365pt_BR
dc.identifier.doi10.3389/fnagi.2016.00097pt_BR
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84974560104&partnerID=40&md5=a40e6b13745185469901d76a02874e22pt_BR
dc.date.available2016-12-06T17:43:16Z-
dc.date.accessioned2016-12-06T17:43:16Z-
dc.description.provenanceMade available in DSpace on 2016-12-06T17:43:16Z (GMT). No. of bitstreams: 1 2-s2.0-84974560104.pdf: 3376341 bytes, checksum: 4329993a4027cda87d7fa0cd61891f35 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/319286-
dc.identifier.idScopus2-s2.0-84974560104pt_BR
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