Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/31218
Type: Artigo de periódico
Title: The prima donna of epigenetics: the regulation of gene expression by DNA methylation
Author: Santos, K.F.
Mazzola, T.N.
Carvalho, H.F.
Abstract: This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.
Subject: Epigenetics
DNA methylation
Inheritable changes in gene expression
Transgenerational carcinogenesis
Environmental influence on memory formation
Editor: Associação Brasileira de Divulgação Científica
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2005001000010
Address: http://dx.doi.org/10.1590/S0100-879X2005001000010
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000010
Date Issue: 1-Oct-2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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