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Type: Artigo de periódico
Title: Maternal age and Down syndrome in Southeastern Brazil
Author: Beiguelman, Bernardo
Krieger, Henrique
Silva, Luciana Marques da
Abstract: The proportion of maternal-age-independent patients estimated among 200 Brazilian Down syndrome children (59.6%) was significantly larger than that of maternal-age-dependent cases (40.4%). The latter proportion is the smallest observed in pertinent literature and due basically to the low mean maternal age of the population analyzed. Based on the remarkable correlation (r = 0.95) between the proportion of maternal-age-dependent patients and the mean maternal age of the general population, a simple predictive equation to estimate the proportion of maternal-age-dependent Down syndrome patients based on the mean maternal age of the general population is suggested in situations where reliable data on the incidence of this syndrome according to maternal age is not available.
Subject: maternal age
Down syndrome
Southeastern Brazil
Editor: Sociedade Brasileira de Genética
Rights: aberto
Identifier DOI: 10.1590/S0100-84551996000400020
Date Issue: 1-Jan-1996
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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