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Type: Artigo de periódico
Title: Cashew apple juice as microbial cultivation medium for non-immunogenic hyaluronic acid production
Author: Oliveira, Adriano H.
Ogrodowski, Cristiane C.
Macedo, André C. de
Santana, Maria Helena A.
Gonçalves, Luciana R.B.
Abstract: In this work, natural cashew apple juice was used as cultivation medium as an alternative to substitute brain heart infusion medium. The effect of aeration and juice supplementation with yeast extract on the production of hyaluronic acid in batch fermentation was also investigated. Similar levels of cell mass were obtained in inoculum using cashew apple juice supplemented with yeast extract or the conventional brain heart infusion medium. Fermentation in Erlenmeyer flasks produced low biomass and hyaluronic acid concentrations. The hyaluronic acid concentration and viscosity increased from 0.15 g/L and 3.87 cP (no aeration or medium supplementation) to 1.76 g/L and 107 cP, when aeration (2 vvm) and 60 g/L of yeast extract were used. The results suggest the production of low-molecular weight hyaluronic acid oligomers instead of the high molecular weight polymer.
Subject: hyaluronic acid
cashew apple juice
submerged fermentation
Editor: Sociedade Brasileira de Microbiologia
Rights: aberto
Identifier DOI: 10.1590/S1517-83822014005000017
Date Issue: 1-Dec-2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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