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Type: Artigo de periódico
Title: Early and late oral features of chronic graft-versus-host disease
Author: Gomes, Alessandra Oliveira Ferrari
Torres, Sandra Regina
Maiolino, Angelo
Santos, Cesar Werneck Noce dos
Silva Junior, Arley
Correa, Maria Elvira Pizzigatti
Moreira, Maria Claudia Rodrigues
Goncalves, Lucio de Souza
Abstract: Background:Chronic graft-versus-host disease is a serious complication of allogeneic hematopoietic cell transplantation, and the mouth is one of the affected sites.Objective:The aim of this study was to evaluate the oral features of this disease after hematopoietic cell transplantation.Methods:This was a cross-sectional multicenter study that enrolled patients submitted to transplantation. Oral evaluations used the National Institutes of Health criteria, salivary flow rates, and the range of mouth opening. Pain and xerostomia were evaluated through a visual analogue scale. Patients were divided into two groups based on the transplantation time (up to one year and more than one year).Results:Of the 57 evaluated recipients, 44 had chronic graft-versus-host disease: ten (22.72%) in the group with less than one year after transplantation, and 34 (77.27%) in the group with more than one year after transplantation. Lichenoid/hyperkeratotic plaques, erythematous lesions, xerostomia, and hyposalivation were the most commonly reported oral features. Lichenoid/hyperkeratotic plaques were significantly more common in patients within the first year after the transplant. The labial mucosa was affected more in the first year. No significant changes occurred in the frequency of xerostomia, hyposalivation, and reduced mouth opening regarding time after transplantation.Conclusion:Oral chronic graft-versus-host disease lesions were identified early in the course of the disease. The changes observed in salivary gland function and in the range of mouth opening were not correlated with the time after transplantation.
Subject: Chronic disease
Hematopoietic stem cell transplantation
Diagnosis, oral
Graft-versus-host disease
Editor: Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea
Citation: Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea, v. 36, n. 1, p. 43-49, 2014.
Rights: aberto
Identifier DOI: 10.5581/1516-8484.20140012
Date Issue: 1-Jan-2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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