Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/27298
Type: Artigo de periódico
Title: T-Cell Lymphomas in South America and Europe
Author: Bellei, Monica
Chiattone, Carlos Sergio
Luminari, Stefano
Pesce, Emanuela Anna
Cabrera, Maria Elena
Souza, Carmino Antonio de
Gabús, Raul
Zoppegno, Lucia
Milone, Jorge
Pavlovsky, Astrid
Connors, Joseph Michael
Foss, Francine Mary
Horwitz, Steven Michael
Liang, Raymond
Montoto, Silvia
Pileri, Stefano Aldo
Polliack, Aaron
Vose, Julie Marie
Zinzani, Pier Luigi
Zucca, Emanuele
Federico, Massimo
Abstract: Peripheral T-cell lymphomas are a group of rare neoplasms originating from clonal proliferation of mature post-thymic lymphocytes with different entities having specific biological characteristics and clinical features. As natural killer cells are closely related to T-cells, natural killer-cell lymphomas are also part of the group. The current World Health Organization classification recognizes four categories of T/natural killer-cell lymphomas with respect to their presentation: disseminated (leukemic), nodal, extranodal and cutaneous. Geographic variations in the distribution of these diseases are well documented: nodal subtypes are more frequent in Europe and North America, while extranodal forms, including natural killer-cell lymphomas, occur almost exclusively in Asia and South America. On the whole, T-cell lymphomas are more common in Asia than in western countries, usually affect adults, with a higher tendency in men, and, excluding a few subtypes, usually have an aggressive course and poor prognosis. Apart from anaplastic lymphoma kinase-positive anaplastic large cell lymphoma, that have a good outcome, other nodal and extranodal forms have a 5-year overall survival of about 30%. According to the principal prognostic indexes, the majority of patients are allocated to the unfavorable subset. In the past, the rarity of these diseases prevented progress in the understanding of their biology and improvements in the efficaciousness of therapy. Recently, international projects devoted to these diseases created networks promoting investigations on T-cell lymphomas. These projects are the basis of forthcoming cooperative, large scale trials to detail biologic characteristics of each sub-entity and to possibly individuate targets for new therapies.
Subject: Lymphoma, T-cell
Killer-cells, natural
Prognosis
Lymphoma, T- cell
Lymphoma, T-Cell
Hematologic neoplasms
South America
Europe
Editor: Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea
Rights: aberto
Identifier DOI: 10.5581/1516-8484.20120013
Address: http://dx.doi.org/10.5581/1516-8484.20120013
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842012000100013
Date Issue: 1-Jan-2012
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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