Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/27291
Type: Artigo de periódico
Title: Importance of killer immunoglobulin-like receptors in allogeneic hematopoietic stem cell transplantation
Author: Franceschi, Danilo Santana Alessio
Souza, Cármino Antonio de
Aranha, Francisco José Penteado
Cardozo, Daniela Maira
Sell, Ana Maria
Visentainer, Jeane Eliete Laguila
Abstract: Hematopoietic stem cell transplantation is the treatment of choice for many hematologic diseases, such as multiple myeloma, bone marrow aplasia and leukemia. Human leukocyte antigen (HLA) compatibility is an important tool to prevent post-transplant complications such as graft rejection and graft-versus-host disease, but the high rates of relapse limit the survival of transplant patients. Natural Killer cells, a type of lymphocyte that is a key element in the defense against tumor cells, cells infected with viruses and intracellular microbes, have different receptors on their surfaces that regulate their cytotoxicity. Killer immunoglobulin-like receptors are the most important, interacting consistently with human leukocyte antigen class I molecules present in other cells and thus controlling the activation of natural killer cells. Several studies have shown that certain combinations of killer immunoglobulin-like receptors and human leukocyte antigens (in both donors and recipients) can affect the chances of survival of transplant patients, particularly in relation to the graft-versusleukemia effect, which may be associated to decreased relapse rates in certain groups. This review aims to shed light on the mechanisms and effects of killer immunoglobulin-like receptors - human leukocyte antigen associations and their implications following hematopoietic stem cell transplantation, and to critically analyze the results obtained by the studies presented herein.
Subject: Hematopoietic stem cell
Histocompatibility testing
Receptor KIR
HLA antigens
Killer cells, natural
Graft vs host disease
Editor: Associação Brasileira de Hematologia e Hemoterapia e daSociedade Brasileira de Transplante de Medula Óssea
Rights: aberto
Identifier DOI: 10.5581/1516-8484.20110033
Address: http://dx.doi.org/10.5581/1516-8484.20110033
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000200011
Date Issue: 1-Jan-2011
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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