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Type: Artigo de periódico
Title: Endothelial wall thickness, cardiorespiratory fitness and inflammatory markers in obese and non-obese adolescents
Author: Silva, Larissa R.
Cavaglieri, Cláudia
Lopes, Wendell A.
Pizzi, Juliana
Coelho-e-Silva, Manuel J. C.
Leite, Neiva
Abstract: Background:Increased carotid intima-media thickness (c-IMT) is considered a marker of early-onset atherosclerosis and it has been found in obese children and adolescents, but the risk factors associated with this population remain to be elucidated.Objective : To compare and verify the relationship between c-IMT, metabolic profile, inflammatory markers, and cardiorespiratory fitness in obese and non-obese children and adolescents.Method : Thirty-five obese subjects (19 boys) and 18 non-obese subjects (9 boys), aged 10-16 years, were included. Anthropometry, body composition, blood pressure, maximal oxygen consumption (VO2max), and basal metabolic rate were evaluated. Serum glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, C-reactive protein (CRP), and adiponectin were assessed. c-IMT was measured by ultrasound.Results:The results showed that c-IMT, triglycerides, insulin, HOMA-IR, and CRP values were significantly higher in the obese group than in the non-obese group, and high-density lipoprotein cholesterol (HDL-c), adiponectin, and VO2max values were significantly lower in the obese group than in the non-obese group. The c-IMT was directly correlated with body weight, waist circumference, % body fat, and HOMA-IR and inversely correlated with % free fat mass, HDL-c, and VO2max.Conclusions : Our findings show that c-IMT correlates not only with body composition, lipids, insulin resistance, and inflammation but also with low VO2max values in children and adolescents.
Subject: obesity
physical therapy
Editor: Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia
Rights: aberto
Identifier DOI: 10.1590/S1413-35552012005000133
Date Issue: 1-Mar-2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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