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Type: Artigo de periódico
Title: Diastereoselective synthesis of β-piperonyl-γ-butyrolactones from morita-baylis-hillman adducts. highly efficient synthesis of (±)-yatein, (±)-podorhizol and (±)-epi-podorhizol
Author: Trazzi, Giordano
André, Marcelo Fabiano
Coelho, Fernando
Abstract: Starting from a Morita-Baylis-Hillman adduct we describe a simple and very efficient method for the diastereoselective preparation of hydroxylated β-Piperonyl-γ-Butyrolactones. To exemplify the efficiency of this approach we also describe a highly efficient synthesis for the biologically active lignans (±)-yatein, (±)-podorhizol and (±)-epi-podorhizol.
Descrevemos nesse trabalho um método simples e eficiente para a preparação diastereosseletiva de b-piperonil-g-butirolactonas hidroxiladas, a partir de um aduto de Morita-Baylis-Hillman. Para exemplificar a eficiência dessa abordagem descrevemos também as sínteses das lignanas biologicamente ativas, (±)-yateína, (±)-podorizol e (±)-epi-podorizol.
Subject: Morita-Baylis-Hillman
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0103-50532010001200021
Date Issue: 1-Dec-2010
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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