Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/25314
Type: Artigo de periódico
Title: A new polyacetylene from Vernonia scorpioides (Lam.) Pers. (Asteraceae) and its in vitro antitumoral activity
Author: Buskuhl, Humberto
Freitas, Rilton A.
Monache, Franco Delle
Barison, Andersson
Campos, Francinete R.
Corilo, Yuri E.
Eberlin, Marcos N.
Biavatti, Maique W.
Abstract: The dichloromethane fraction obtained from hydroalcoholic crude extract of leaves and flowers of Vernonia scorpioides (Asteraceae) was investigated, resulting in the isolation and structure elucidation of a new polyacetylene namely 5-octa-2,4,6-triynyl-furan-2(5H)-one. The structure of the isolated compound was determined based on IR, NMR (1D and 2D) and MS spectrometric data. The antitumor potential, including cytotoxicity to tumor cells and genotoxicity, was investigated. The results suggest that apoptotic cell death may have occurred, at least in part, via a caspase-dependent mechanism.
A fração diclorometano obtida pelo particionamento do extrato hidroalcoólico obtido das folhas e flores de Vernonia scorpioides (Asteraceae) resultou no isolamento e caracterização de um novo poliacetileno, 5-octa-2,4,6-triinil-furan-2(5H)-ona. A determinação estrutural foi baseada em dados de espectrometria de Ressonância Magnética Nuclear mono e bidimensionais, de Massas e de Infravermelho. Foi investigado o potencial antitumoral e genotóxico do novo poliacetileno e os resultados encontrados sugerem genotoxicidade e citotoxicidade, onde a morte celular ocorreu via apoptose, envolvendo um mecanismo dependente de caspase.
Subject: polyacetylene
Vernonia scorpioides
cytotoxicity
genotoxicity
Asteraceae
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0103-50532009000700018
Address: http://dx.doi.org/10.1590/S0103-50532009000700018
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000700018
Date Issue: 1-Jan-2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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