Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: An easy and efficient method to produce gamma-amino alcohols by reduction of beta-enamino ketones
Author: Harris, Maria Inês N. C.
Braga, Antonio C. H.
Abstract: Reduction of beta-enamino ketones 2 with NaBH4 in glacial acetic acid gave gamma-amino alcohols 1 in 70% to 98% yield with diastereomeric excesses, preferentially the syn product, from 44% to 90%. The stereochemistry of these compounds was confirmed by analysis of their tetrahydro-1,3-oxazine derivatives 3.
A redução de beta-enamino cetonas 2 com NaBH4 em ácido acético glacial produziu gama-amino álcoois 1 em 70% a 98% de rendimento, com excessos diastereoméricos, preferencialmente o produto syn, de 44% a 90%. A estereoquímica desses compostos foi confirmada pela análise de seus derivados tetraidro-1,3-oxazinas 3.
Subject: amino alcohols
enamino ketones
stereoselective reduction
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0103-50532004000600027
Date Issue: 1-Dec-2004
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
File Description SizeFormat 
S0103-50532004000600027.pdf150.28 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.