Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/2485
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePost-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3pt_BR
dc.contributor.authorBigarella, Carolina L.pt_BR
dc.contributor.authorVieira Ferro, Karla P.pt_BR
dc.contributor.authorBarcellos, Karin S. A.pt_BR
dc.contributor.authorMartins-de-Souza, Danielpt_BR
dc.contributor.authorTraina, Fabiolapt_BR
dc.contributor.authorNovello, Jose C.pt_BR
dc.contributor.authorOlalla Saad, Sara T.pt_BR
dc.contributor.authorArchangelo, Leticia Froehlichpt_BR
unicamp.authorBigarella, Carolina L.pt_BR
unicamp.authorVieira Ferro, Karla P.pt_BR
unicamp.authorBarcellos, Karin S. A.pt_BR
unicamp.authorTraina, Fabiolapt_BR
unicamp.authorNovello, Jose C.pt_BR
unicamp.authorOlalla Saad, Sara T.pt_BR
unicamp.authorArchangelo, Leticia Froehlichpt_BR
unicamp.author.externalMartins-de-Souza, Danielpt
dc.subjectARHGAP21pt_BR
dc.subjectProliferationpt_BR
dc.subjectSUMO2/3pt_BR
dc.subjectPost-translational modificationpt_BR
dc.subject.wosSUMOYLATION SITE PREDICTIONpt_BR
dc.subject.wosRECRUITMENTpt_BR
dc.subject.wosCHAINSpt_BR
dc.description.abstractARHGAP21 is a 217 kDa RhoGAP protein shown to modulate cell migration through the control of Cdc42 and FAK activities. In the present work a 250 kDa-ARHGAP21 was identified by mass spectrometry. This modified form is differentially expressed among cell lines and human primary cells. Co-immunoprecipitations and in vitro SUMOylation confirmed ARHGAP21 specific modification by SUMO2/3 and mapped the SUMOylation site to ARHGAP21 lysine K1443. Immunofluorescence staining revealed that ARHGAP21 co-localizes with SUMO2/3 in the cytoplasm and membrane compartments. Interestingly, our results suggest that ARHGAP21 SUMOylation may be related to cell proliferation. Therefore, SUMOylation of ARHGAP21 may represent a way of guiding its function. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.pt
dc.relation.ispartofFebs Letterspt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisherElsevierpt_BR
dc.date.issued2012pt_BR
dc.identifier.citationFebs Letters. Elsevier, v.586, n.19, p.3522-3528, 2012pt_BR
dc.language.isoengpt_BR
dc.description.volume586pt_BR
dc.description.issuenumber19pt_BR
dc.description.firstpage3522pt_BR
dc.description.lastpage3528pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0014-5793pt_BR
dc.identifier.wosidWOS:000309314200080pt_BR
dc.identifier.doi10.1016/j.febslet.2012.08.012pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2013-09-19T18:06:52Z
dc.date.available2016-06-21T20:06:04Z-
dc.date.accessioned2013-09-19T18:06:52Z
dc.date.accessioned2016-06-21T20:06:04Z-
dc.description.provenanceMade available in DSpace on 2013-09-19T18:06:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2016-06-21T20:06:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2485
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2485-
dc.contributor.departmentHematologia
dc.contributor.unidadeHemocentropt
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