Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/244204
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampAguiar, Marcus Aloizio Martinez dept_BR
dc.contributor.authorunicampSchneider, David Marcelopt_BR
dc.contributor.authorunicampMartins, Ayana de Britopt_BR
dc.typeArtigopt_BR
dc.titleError catastrophe in populations under similarity-essential recombinationpt_BR
dc.contributor.authorAguiar, M. A. M. dept_BR
dc.contributor.authorSchneider, D. M.pt_BR
dc.contributor.authorCarmo, E. dopt_BR
dc.contributor.authorCampos, P. R. A.pt_BR
dc.contributor.authorMartins, A. B.pt_BR
dc.subjectHaplótipospt_BR
dc.subjectEspeciaçãopt_BR
dc.subjectAnálise de erros (Matemática)pt_BR
dc.subject.otherlanguageHaplotypespt_BR
dc.subject.otherlanguageSpeciationpt_BR
dc.subject.otherlanguageError analysis (Mathematics)pt_BR
dc.description.abstractOrganisms are often more likely to exchange genetic information with others that are similar to themselves. One of the most widely accepted mechanisms of RNA virus recombination requires substantial sequence similarity between the parental RNAs and is termed similarity-essential recombination. This mechanism may be considered analogous to assortative mating, an important form of non-random mating that can be found in animals and plants. Here we study the dynamics of haplotype frequencies in populations evolving under similarity-essential recombination. Haplotypes are represented by a genome of B biallelic loci and the Hamming distance between individuals is used as a criterion for recombination. We derive the evolution equations for the haplotype frequencies assuming that recombination does not occur if the genetic distance is larger than a critical value G and that mutation occurs at a rate pi per locus. Additionally, uniform crossover is considered. Although no fitness is directly associated to the haplotypes, we show that frequency-dependent selection emerges dynamically and governs the haplotype distribution. A critical mutation rate it, can be identified as the error threshold transition, beyond which this selective information cannot be stored. For mu < mu(c), the distribution consists of a dominant sequence surrounded by a cloud of closely related sequences, characterizing a quasispecies. For mu > mu(c) the distribution becomes uniform, with all haplotypes having the same frequency. In the case of extreme assortativeness, where individuals only recombine with others identical to themselves (G=0), the error threshold results mu(c) = 1/4, independently of the genome size. For weak assortativity (G = B-1) mu(c) =2(-(B+1)) and for the case of no assortativity (G=B) mu(c)= 0. We compute the mutation threshold for 0 < G < B and show that, for large B, it depends only on the ratio G/B. We discuss the consequences of these results for recombination in viruses and for speciation. (C) 2015 Elsevier Ltd. All rights reserved.en
dc.description.abstractOrganisms are often more likely to exchange genetic information with others that are similar to themselves. One of the most widely accepted mechanisms of RNA virus recombination requires substantial sequence similarity between the parental RNAs and is termed similarity-essential recombination. This mechanism may be considered analogous to assortative mating, an important form of non-random mating that can be found in animals and plants. Here we study the dynamics of haplotype frequencies in populations evolving under similarity-essential recombination. Haplotypes are represented by a genome of B biallelic loci and the Hamming distance between individuals is used as a criterion for recombination. We derive the evolution equations for the haplotype frequencies assuming that recombination does not occur if the genetic distance is larger than a critical value G and that mutation occurs at a rate pi per locus. Additionally, uniform crossover is considered. Although no fitness is directly associated to the haplotypes, we show that frequency-dependent selection emerges dynamically and governs the haplotype distribution. A critical mutation rate it, can be identified as the error threshold transition, beyond which this selective information cannot be stored. For mu < mu(c), the distribution consists of a dominant sequence surrounded by a cloud of closely related sequences, characterizing a quasispecies. For mu > mu(c) the distribution becomes uniform, with all haplotypes having the same frequency. In the case of extreme assortativeness, where individuals only recombine with others identical to themselves (G=0), the error threshold results mu(c) = 1/4, independently of the genome size. For weak assortativity (G = B-1) mu(c) =2(-(B+1)) and for the case of no assortativity (G=B) mu(c)= 0. We compute the mutation threshold for 0 < G < B and show that, for large B, it depends only on the ratio G/B. We discuss the consequences of these results for recombination in viruses and for speciation.pt_BR
dc.relation.ispartofJournal of theoretical biologypt_BR
dc.relation.ispartofabbreviationJ. theor. biol.pt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherAcademic Presspt_BR
dc.date.issued2015pt_BR
dc.date.monthofcirculationJunept_BR
dc.identifier.citationError Catastrophe In Populations Under Similarity-essential Recombination. Academic Press Ltd- Elsevier Science Ltd, v. 374, p. 48-53 Jun-2015.pt_BR
dc.language.isoengpt_BR
dc.description.volume374pt_BR
dc.description.firstpage48pt_BR
dc.description.lastpage53pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0022-5193pt_BR
dc.identifier.eissn1095-8541pt_BR
dc.identifier.doi10.1016/j.jtbi.2015.03.028pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0022519315001435pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorshipCNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsordocumentnumberFAPESP [2014/04036-2, 2011/18622-2, 2014/10470-7]pt
dc.description.sponsordocumentnumberCNPq [303497/2014-9, 470598/2012-3]pt
dc.description.sponsordocumentnumber2011/18622-2pt_BR
dc.description.sponsordocumentnumber2014/04036-2pt_BR
dc.description.sponsordocumentnumber2014/10470-7pt_BR
dc.description.sponsordocumentnumber470598/2012-3pt_BR
dc.description.sponsordocumentnumber303497/2014-9pt_BR
dc.date.available2016-06-07T13:35:49Z-
dc.date.accessioned2016-06-07T13:35:49Z-
dc.description.provenanceMade available in DSpace on 2016-06-07T13:35:49Z (GMT). No. of bitstreams: 1 wos_000354667000005.pdf: 335002 bytes, checksum: 9786f4752632b5e3f85fee3be53948f4 (MD5) Previous issue date: 2015 Bitstreams deleted on 2020-09-02T13:41:20Z: wos_000354667000005.pdf,. Added 1 bitstream(s) on 2020-09-02T13:45:31Z : No. of bitstreams: 1 000354667000005.pdf: 410161 bytes, checksum: 042b3612162c5ba419dc8787655b41e6 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/244204-
dc.contributor.departmentDepartamento de Física da Matéria Condensadapt_BR
dc.contributor.departmentDepartamento de Física da Matéria Condensadapt_BR
dc.contributor.departmentDepartamento de Física da Matéria Condensadapt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.contributor.unidadeInstituto de Física Gleb Wataghinpt_BR
dc.subject.keywordHaplotype frequenciespt_BR
dc.subject.keywordFrequency-dependent selectionpt_BR
dc.subject.keywordQuasispecies theorypt_BR
dc.subject.keywordNeutral modelspt_BR
dc.identifier.source000354667000005pt_BR
dc.creator.orcid0000-0003-1379-7568pt_BR
dc.creator.orcid0000-0002-0124-8759pt_BR
dc.creator.orcid0000-0003-3106-3365pt_BR
dc.type.formArtigopt_BR
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