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|Type:||Artigo de periódico|
|Title:||Evidence that polymorphisms in detoxification genes modulate the susceptibility for sporadic medullary thyroid carcinoma|
|Author:||Barbieri, R. B.|
Bufalo, N. E.
Silva, A. C. N.
Assumpcao, L. V. M.
Maciel, R. M. B.
Cerutti, J. M.
Ward, L. S.
|Abstract:||Aim: Polymorphic low-penetrance genes have been consistently associated with the susceptibility to a series of human tumors, including differentiated thyroid cancer. Methods: To determine their role in medullary thyroid cancer (MTC), we used TaqMan SNP method to genotype 47 sporadic MTC (s-MTC) and a control group of 578 healthy individuals for CYP1A2* F, CYP1A1m1, GSTP1, NAT2 and 72TP53. A logistic regression analysis showed that NAT2C/C (OR=3.87; 95% CI=2.11-7.10; P=2.2 x 10(-5)) and TP53C/C genotypes (OR=3.87; 95% CI=1.78-6.10; P=2.8 x 10(-4)) inheritance increased the risk of s-MTC. A stepwise regression analysis indicated that TP53C/C genotype contributes with 8.07% of the s-MTC risk. Results: We were unable to identify any relationship between NAT2 and TP53 polymorphisms suggesting they are independent factors of risk to s-MTC. In addition, there was no association between the investigated genes and clinical or pathological features of aggressiveness of the tumors or the outcome of MTC patients. Conclusion: In conclusion, we demonstrated that detoxification genes and apoptotic and cell cycle control genes are involved in the susceptibility of s-MTC and may modulate the susceptibility to the disease.|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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