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Type: Artigo de periódico
Title: Species-wide Whole Genome Sequencing Reveals Historical Global Spread And Recent Local Persistence In Shigella Flexneri
Author: Connor
Thomas R.; Barker
Clare R.; Baker
Kate S.; Weill
Francois-Xavier; Talukder
Kaisar Ali; Smith
Anthony M.; Stephen Baker; Gouali
Malika; Duy Pham Thanh; Azmi
Ishrat Jahan; da Silveira
Wanderley Dias; Semmler
Torsten; Wieler
Lothar H.; Jenkins
Claire; Cravioto
Alejandro; Faruque
Shah M.; Parkhill
Julian; Kim
Dong Wook; Keddy
Karen H.; Thomson
Nicholas R.
Abstract: Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis subdivides S. flexneri into seven phylogenetic groups (PGs); each containing two-or-more serotypes and characterised by distinct virulence gene complement and geographic range. Within the S. flexneri PGs we identify geographically restricted sub-lineages that appear to have persistently colonised regions for many decades to over 100 years. Although we found abundant evidence of antimicrobial resistance (AMR) determinant acquisition, our dataset shows no evidence of subsequent intercontinental spread of antimicrobial resistant strains. The pattern of colonisation and AMR gene acquisition suggest that S. flexneri has a distinct life-cycle involving local persistence. DOI: 10.7554/eLife.07335.001
Subject: O-antigen Modification
Pathogenicity Island
Enteric Multicenter
Vaccine Development
Asian Countries
Baps Software
Rights: aberto
Identifier DOI: 10.7554/eLife.07335
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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