Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/244005
Type: Artigo
Title: Beta-glucans (saccharomyces cereviseae) reduce glucose levels and attenuate alveolar bone loss in diabetic rats with periodontal disease
Author: Silva, Viviam de Oliveira
Lobato, Raquel Vieira
Andrade, Eric Francelino
de Macedo, Cristina Gomes
Clemente Napimoga, Juliana Trindade
Napimoga, Marcelo Henrique
Messora, Michel Reis
Murata, Ramiro Mendonca
Pereira, Luciano José
Abstract: The objective of this study was to assess the effects of oral ingestion of beta-glucans isolated from Saccharomyces cereviseae on the metabolic profile, expression of gingival inflammatory markers and amount of alveolar bone loss in diabetic rats with periodontal disease. Diabetes mellitus was induced in 48 Wistar rats by intraperitoneal injection of streptozotocin (80 mg/kg). After confirming the diabetes diagnosis, the animals were treated with beta-glucans (by gavage) for 28 days. On the 14th day of this period, periodontal disease was induced using a ligature protocol. beta-glucans reduced the amount of alveolar bone loss in animals with periodontal disease in both the diabetic and non-diabetic groups (p < 0.05). beta-glucans reduced blood glucose, cholesterol and triacylglycerol levels in diabetic animals, both with and without periodontal disease (p < 0.05). Furthermore, treatment with beta-glucans reduced the expression of cyclooxygenase-2 and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin expression in animals with diabetes and periodontal disease (p < 0.05). It was concluded that treatment with beta-glucans has beneficial metabolic and periodontal effects in diabetic rats with periodontal disease.
The objective of this study was to assess the effects of oral ingestion of beta-glucans isolated from Saccharomyces cereviseae on the metabolic profile, expression of gingival inflammatory markers and amount of alveolar bone loss in diabetic rats with periodontal disease. Diabetes mellitus was induced in 48 Wistar rats by intraperitoneal injection of streptozotocin (80 mg/kg). After confirming the diabetes diagnosis, the animals were treated with beta-glucans (by gavage) for 28 days. On the 14th day of this period, periodontal disease was induced using a ligature protocol. beta-glucans reduced the amount of alveolar bone loss in animals with periodontal disease in both the diabetic and non-diabetic groups (p < 0.05). beta-glucans reduced blood glucose, cholesterol and triacylglycerol levels in diabetic animals, both with and without periodontal disease (p < 0.05). Furthermore, treatment with beta-glucans reduced the expression of cyclooxygenase-2 and receptor activator of nuclear factor kappa-B ligand and increased osteoprotegerin expression in animals with diabetes and periodontal disease (p < 0.05). It was concluded that treatment with beta-glucans has beneficial metabolic and periodontal effects in diabetic rats with periodontal disease
Subject: Imunidade
Glicose
Doenças periodontais
Ratos
Country: Estados Unidos
Editor: Public Library of Science
Citation: Beta-glucans (saccharomyces Cereviseae) Reduce Glucose Levels And Attenuate Alveolar Bone Loss In Diabetic Rats With Periodontal Disease. Public Library Science, v. 10, p. AUG-2015.
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0134742
Address: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134742
Date Issue: 2015
Appears in Collections:FOP - Artigos e Outros Documentos

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