Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: In Vivo Biocompatibility Of Nanostructured Chitosan/peo Membranes
Author: Vulcani
V. A. S.; Franzo
V. S.; Rabelo
R. E.; Rabbers
A. S.; Assis
B. M.; D'Avila
M. A.; Antoni
S. M. B.
Abstract: Electrospinning is a technique that allows the preparation of nanofibers from various materials. Chitosan is a natural and abundant easily obtained polymer, which, in addition to those features, proved to be biocompatible. This work used nanostructured chitosan and polyoxyethylene membranes as subcutaneous implants in Wistar rats to evaluate the biocompatibility of the material. Samples of the material and tissues adjacent to the implant were collected 7, 15, 30, 45 and 60 days post-implantation. Macroscopic integration of the material to the tissues was observed in the samples and slides for histopathological examination that were prepared. It was noticed that the material does not stimulate the formation of adherences to the surrounding tissues and that there is initial predominance of neutrophilia and lymphocytosis, with a declining trend according to the increase of time, featuring a non-persistent acute inflammatory process. However, the material showed fast degradation, impairing the macroscopic observation after fifteen days of implantation. It was concluded that the material is biocompatible and that new studies should be conducted, modifying the time of degradation by changes in obtaining methods and verifying the biocompatibility in specific tissues for biomedical applications.
Subject: Veterinary Sciences
Citation: In Vivo Biocompatibility Of Nanostructured Chitosan/peo Membranes. Arquivo Brasileiro Medicina Veterinaria Zootecnia, v. 67, p. 1039-1044 AUG-2015.
Rights: fechado
Identifier DOI: 10.1590/1678-4162-8286
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
wos_000361545400012.pdf420.6 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.