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Type: Artigo de periódico
Title: Role Of Mmp-2 And Mmp-9 In Resistance To Drug Therapy In Patients With Resistant Hypertension
Author: Lacerda
Leandro; de Faria
Ana Paula; Fontana
Vanessa; Moreno
Heitor; Sandrim
Abstract: Background: Despite the increased evidence of the important role of matrix metalloproteinases (MMP-9 and MMP-2) in the pathophysiology of hypertension, the profile of these molecules in resistant hypertension (RHTN) remains unknown. Objectives: To compare the plasma levels of MMP-9 and MMP-2 and of their tissue inhibitors (TIMP-1 and TIMP-2, respectively), as well as their MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios, between patients with controlled RHTN (CRHTN, n = 41) and uncontrolled RHTN (UCRHTN, n = 35). In addition, the association of those parameters with clinical characteristics, office blood pressure (BP) and arterial stiffness (determined by pulse wave velocity) was evaluate in those subgroups. Methods: This study included 76 individuals diagnosed with RHTN and submitted to physical examination, electrocardiogram, and laboratory tests to assess biochemical parameters. Results: Similar values of MMP-9, MMP-2, TIMP-1, TIMP-2, and MMP-9/1IMP-1 and MMP-2/TIMP-2 ratios were found in the UCRHTN and CRHTN subgroups (p > 0.05). A significant correlation was found between diastolic BP (DBP) and MMP-9/TIMP-1 ratio (r = 0.37; p = 0.02) and DPB and MMP-2 (r = -0.40; p = 0.02) in the UCRHTN subgroup. On the other hand, no correlation was observed in the CRHTN subgroup. Logistic regression models demonstrated that MMP-9, MMP-2, TIMP-1, TIMP-2 and their ratios were not associated with the lack of BP control. Conclusion: These findings suggest that neither MMP-2 nor MMP-9 affect BP control in RHTN subjects.
Subject: Circulating Matrix Metalloproteinases
Primary Aldosteronism
Arterial Stiffness
Tissue Inhibitor
Rights: fechado
Identifier DOI: 10.5935/abc.20150060
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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