Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/243869
Type: Artigo
Title: Intake of Passiflora edulis leaf extract improves antioxidant and anti-inflammatory status in rats with 2,4,6-trinitrobenzenesulphonic acid induced colitis
Author: Cazarin, Cinthia Baú Betim
Silva, Juliana Kelly da
Colomeu, Talita Cristina
Batista, Ângela Giovana
Meletti, Laura Maria Molina
Paschoal, Jonas Augusto Rizzato
Bogusz Junior, Stanislau
Braga, Campos, Patrícia Aparecida de
Reyes Reyes, Felix Guillermo
Augusto, Fábio
Meirelles, Luciana Rodrigues de
Zollner, Ricardo de Lima
Maróstica Júnior, Mário Roberto
Abstract: The antioxidant and anti-inflammatory effects of the aqueous extract of Passiflora edulis leaves, which is a source of vitexin, isovitexin and isoorientin, was investigated in a 2,4,6-trinitrobenzenesulphonic acid induced colitis model. The oral intake of P. edulis extract (1100 mu g mL(-1)) improved significantly (P < 0.05) the endogenous antioxidant status and decreased lipid peroxidation in serum, liver, and colon. The consumption of P. edulis extract decreased the level of pro-inflammatory in colon tissue, especially by reducing IL-1 beta fivefold and TNF-alpha two-fold compared to the control colitis group. The extract of P. edulis leaves possessed therapeutic activity in healthy rats and in TNBS-induced colitis, especially by controlling the oxidative stress and inflammation observed in this disease. (C) 2015 Elsevier Ltd. All rights reserved.
The antioxidant and anti-inflammatory effects of the aqueous extract of Passiflora edulis leaves, which is a source of vitexin, isovitexin and isoorientin, was investigated in a 2,4,6-trinitrobenzenesulphonic acid induced colitis model. The oral intake of P. edulis extract (1100 mu g mL(-1)) improved significantly (P < 0.05) the endogenous antioxidant status and decreased lipid peroxidation in serum, liver, and colon. The consumption of P. edulis extract decreased the level of pro-inflammatory in colon tissue, especially by reducing IL-1 beta fivefold and TNF-alpha two-fold compared to the control colitis group. The extract of P. edulis leaves possessed therapeutic activity in healthy rats and in TNBS-induced colitis, especially by controlling the oxidative stress and inflammation observed in this disease. (C) 2015 Elsevier Ltd. All rights reserved
Subject: Estresse oxidativo
Colite
Country: Países Baixos
Editor: Elsevier
Citation: Intake Of Passiflora Edulis Leaf Extract Improves Antioxidant And Anti-inflammatory Status In Rats With 2,4,6-trinitrobenzenesulphonic Acid Induced Colitis. Elsevier Science Bv, v. 17, p. 575-586 AUG-2015.
Rights: fechado
Identifier DOI: 10.1016/j.jff.2015.05.034
Address: http://www.sciencedirect.com/science/article/pii/S1756464615002728
Date Issue: 2015
Appears in Collections:IQ - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

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